The Radiation Sciences Program brings together laboratory and clinical investigators and clinicians Interested in the biological effects of radiation and the use of radiation therapy for cancer treatment. The program consists of 26 members from 8 different departments. Since the last funding cycle the research base for the Radiation Sciences Program increased 48% from $4,142,697 to $6,112,068 total annual direct research support, of which $4,065,571 is from the NCI. Over this last grant period, there were 278 publications of Radiation Science Program members, of which 18.7% are intra-programmatic and 44.2% are inter-programmatic. The members are divided into two chief interest groups: The biology interest group consists of investigators studying basic mechanisms of how cells respond to DNIA-damaging agents. A better understanding of these fundamental basic mechanisms in normal and cancer cells is critical in guiding the development of improved use of radiation in the clinic. Some of the specific areas studied by members of this interest group Include: Induction of DNA damage;mechanisms of DNA double strand break repair;regulation of DNA damage signal transduction;activation of cell cycle checkpoints;mechanisms of DNA damage-induced cell death;gene therapy for cancer treatment;molecular targets of radiosensitization;DNA damage-induced gene expression;mechanism of replication stress in cancer cells;and, genomic instability The medical physics Interest group consists of investigators applying physics to the practice of radiation oncology. This group has a long track record of developing novel highly conformal radiation therapy techniques. This group has strong interactions with many clinical programs in the Cancer Center including Head and Neck, GI, Lung, Breast, and Prostate. In addition, this group has worked with clinicians in neuro-oncology and with the Molecular Imaging Program to develop new methods of functional imaging in the CNS. Specific topics of Interest include developing new methods of: dose calculation;optimization;assessment and correction of geometric uncertainties;image registration;constructing 4-D models of patients for planning;treatment delivery;and, imaging patients or tumors in real time during treatment

Public Health Relevance

The research undertaken by the members of the Radiation Sciences Program are of significant relevance to public health both for the understanding of the human health threats of radiation exposure as well as for improved uses of radiation in cancer treatment.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Michigan Ann Arbor
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Owen, John Henry; Graham, Martin P; Chinn, Steven B et al. (2016) Novel method of cell line establishment utilizing fluorescence-activated cell sorting resulting in 6 new head and neck squamous cell carcinoma lines. Head Neck 38 Suppl 1:E459-67
Lee, Alice W; Ness, Roberta B; Roman, Lynda D et al. (2016) Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk. Obstet Gynecol 127:828-36
Mathewson, Nathan D; Jenq, Robert; Mathew, Anna V et al. (2016) Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease. Nat Immunol 17:505-13
Boonstra, Philip S; Mukherjee, Bhramar; Gruber, Stephen B et al. (2016) Tests for Gene-Environment Interactions and Joint Effects With Exposure Misclassification. Am J Epidemiol 183:237-47
Peng, Dongjun; Tanikawa, Takashi; Li, Wei et al. (2016) Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling. Cancer Res 76:3156-65
Kadakia, Kunal C; Snyder, Claire F; Kidwell, Kelley M et al. (2016) Patient-Reported Outcomes and Early Discontinuation in Aromatase Inhibitor-Treated Postmenopausal Women With Early Stage Breast Cancer. Oncologist 21:539-46
Boonstra, Philip S; Taylor, Jeremy M G; Smolska-Ciszewska, Beata et al. (2016) Alpha/beta (α/β) ratio for prostate cancer derived from external beam radiotherapy and brachytherapy boost. Br J Radiol 89:20150957
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Hardiman, Karin M; Ulintz, Peter J; Kuick, Rork D et al. (2016) Intra-tumor genetic heterogeneity in rectal cancer. Lab Invest 96:4-15
Zhao, Ende; Maj, Tomasz; Kryczek, Ilona et al. (2016) Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nat Immunol 17:95-103

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