The Microscopy and Image-analysis Laboratory (MIL) serves as the Morphology Core for the University of Michigan Comprehensive Cancer Center (UMCCC). The MIL was established in 1977 as a University wide shared user microscopy and imaging facility and became a UMCCC Core Facility in 1995. All instrumentation is used on a shared basis by investigators for studies of cell and tissue morphology and ultrastructure. The MIL Is housed and administered within the Department of Cell &Developmental Biology at the University of Michigan Medical School. The Morphology Core offers a cost-effective mechanism for UMCCC researchers to have access to state-of-the-art imaging instrumentation that would not otherwise be available in Individual laboratories because of high acquisition and maintenance costs. Access to highly trained personnel with many years of expertise is also provided by the Morphology Core and is available to all UMCCC members and their staff. The MIL is staffed by a full time manager, a laboratory supervisor, five research associates, and Instrument analyst. Routine histology and electron microscopy sample processing, sectioning, staining, and analysis is available with prior consultation and scheduling. Emphasis Is placed on training the research investigator or their designated staff to properly operate each piece of equipment as needed to meet their imaging research needs.
The use of high-end Imaging instruments have become a standard which research investigators have relied on to understand the mechanisms of disease to combat cancer, in cells and tissues. The UMCCC Morphology Core offers these instruments to our Investigators on a shared use basis as a cost effective mechanism to investigate ongoing funded research projects.
|Mathewson, Nathan D; Jenq, Robert; Mathew, Anna V et al. (2016) Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease. Nat Immunol 17:505-13|
|Owen, John Henry; Graham, Martin P; Chinn, Steven B et al. (2016) Novel method of cell line establishment utilizing fluorescence-activated cell sorting resulting in 6 new head and neck squamous cell carcinoma lines. Head Neck 38 Suppl 1:E459-67|
|Lee, Alice W; Ness, Roberta B; Roman, Lynda D et al. (2016) Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk. Obstet Gynecol 127:828-36|
|Kadakia, Kunal C; Snyder, Claire F; Kidwell, Kelley M et al. (2016) Patient-Reported Outcomes and Early Discontinuation in Aromatase Inhibitor-Treated Postmenopausal Women With Early Stage Breast Cancer. Oncologist 21:539-46|
|Boonstra, Philip S; Mukherjee, Bhramar; Gruber, Stephen B et al. (2016) Tests for Gene-Environment Interactions and Joint Effects With Exposure Misclassification. Am J Epidemiol 183:237-47|
|Peng, Dongjun; Tanikawa, Takashi; Li, Wei et al. (2016) Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling. Cancer Res 76:3156-65|
|Hardiman, Karin M; Ulintz, Peter J; Kuick, Rork D et al. (2016) Intra-tumor genetic heterogeneity in rectal cancer. Lab Invest 96:4-15|
|Boonstra, Philip S; Taylor, Jeremy M G; Smolska-Ciszewska, Beata et al. (2016) Alpha/beta (Î±/Î²) ratio for prostate cancer derived from external beam radiotherapy and brachytherapy boost. Br J Radiol 89:20150957|
|Amin, Nisar A; Malek, Sami N (2016) Gene mutations in chronic lymphocytic leukemia. Semin Oncol 43:215-21|
|Zhao, Ende; Maj, Tomasz; Kryczek, Ilona et al. (2016) Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nat Immunol 17:95-103|
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