The Tissue and Molecular Pathology Core (TMPC) consists of several distinct, yet highly interactive services and banks, all related to the procurement, processing and evaluation of tissue for cancer research (see Fig. below). The Tissue Procurement Service collects and distributes surplus human tissue from surgical specimens. Patients are consented for use of their tissues, which can be collected and processed in a variety of ways depending on the specific needs of the investigator. The Histology and immunohistochemistry Service provides expert histology and immunohistochemistry services. The lab uses several automated Immunohistochemistry instruments and offers complete workup of novel antibodies with various antigen retrieval protocols and titrations. The Tissue Microarray Service constructs routine and custom designed tissue microarrays to be used in immunohistochemical, immunofluorescent and in s/fu hybridization assays. The Anonymous Paraffin Bank consists of over 2500 paraffin blocks of normal tissues and tumors of all types collected from surplus surgical tissue. Tissues from this bank are used by the Core and UMCCC Investigators for all types of research activities, primarily tissue microarray construction and immunohistochemical workup of antibodies. The Laser Capture Microdissection Service assists investigators with all aspects of laser capture microdissection. The Frozen Tumor Bank collects surplus human tissue when available, and currently contains over 7500 frozen tissue samples, The Molecular Pathology Research Laboratory offers a full menu of molecular pathology assays with a focus on evaluating frozen and fixed neoplastic human tissues. Collectively, the services of the Tissue and Molecular Pathology Core provide UMCCC investigators access to a wide variety of high-quality mission-critical tissue procurement and evaluation services

Public Health Relevance

The Tissue and Molecular Pathology Core Is directly relevant to cancer research as it provides UMCCC cancer investigators access to human tissue samples and molecular pathology assays. These services generally advance cancer research by facilitating the research of many UMCCC Investigators.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA046592-24
Application #
8300290
Study Section
Subcommittee G - Education (NCI)
Project Start
2012-06-01
Project End
2017-05-31
Budget Start
2012-09-21
Budget End
2013-05-31
Support Year
24
Fiscal Year
2012
Total Cost
$147,889
Indirect Cost
$52,723
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Verhaegen, Monique E; Mangelberger, Doris; Harms, Paul W et al. (2015) Merkel cell polyomavirus small T antigen is oncogenic in transgenic mice. J Invest Dermatol 135:1415-24
Chinn, Steven B; Darr, Owen A; Owen, John H et al. (2015) Cancer stem cells: mediators of tumorigenesis and metastasis in head and neck squamous cell carcinoma. Head Neck 37:317-26
Vainshtein, Jeffrey M; Spector, Matthew E; Stenmark, Matthew H et al. (2014) Reliability of post-chemoradiotherapy F-18-FDG PET/CT for prediction of locoregional failure in human papillomavirus-associated oropharyngeal cancer. Oral Oncol 50:234-9
Castro, Maria G; Candolfi, Marianela; Wilson, Thomas J et al. (2014) Adenoviral vector-mediated gene therapy for gliomas: coming of age. Expert Opin Biol Ther 14:1241-57
Vainshtein, Jeffrey M; Spector, Matthew E; McHugh, Jonathan B et al. (2014) Refining risk stratification for locoregional failure after chemoradiotherapy in human papillomavirus-associated oropharyngeal cancer. Oral Oncol 50:513-9
Grogan, Patrick T; Sarkaria, Jann N; Timmermann, Barbara N et al. (2014) Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation. Invest New Drugs 32:604-17
VanderVeen, Nathan; Paran, Christopher; Appelhans, Ashley et al. (2014) Marmosets as a preclinical model for testing "off-label" use of doxycycline to turn on Flt3L expression from high-capacity adenovirus vectors. Mol Ther Methods Clin Dev 1:
Krook, Melanie A; Nicholls, Lauren A; Scannell, Christopher A et al. (2014) Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma. Mol Cancer Res 12:953-64
Ro, Seung-Hyun; Semple, Ian A; Park, Haewon et al. (2014) Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J 281:3816-27
Stenmark, Matthew H; McHugh, Jonathan B; Schipper, Matthew et al. (2014) Nonendemic HPV-positive nasopharyngeal carcinoma: association with poor prognosis. Int J Radiat Oncol Biol Phys 88:580-8

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