The Microscopy and Image-analysis Laboratory (MIL) serves as the Morphology Core for the University of Michigan Comprehensive Cancer Center (UMCCC). The MIL was established in 1977 as a University wide shared user microscopy and imaging facility and became a UMCCC Core Facility in 1995. All instrumentation is used on a shared basis by investigators for studies of cell and tissue morphology and ultrastructure. The MIL Is housed and administered within the Department of Cell &Developmental Biology at the University of Michigan Medical School. The Morphology Core offers a cost-effective mechanism for UMCCC researchers to have access to state-of-the-art imaging instrumentation that would not otherwise be available in Individual laboratories because of high acquisition and maintenance costs. Access to highly trained personnel with many years of expertise is also provided by the Morphology Core and is available to all UMCCC members and their staff. The MIL is staffed by a full time manager, a laboratory supervisor, five research associates, and Instrument analyst. Routine histology and electron microscopy sample processing, sectioning, staining, and analysis is available with prior consultation and scheduling. Emphasis Is placed on training the research investigator or their designated staff to properly operate each piece of equipment as needed to meet their imaging research needs.

Public Health Relevance

The use of high-end Imaging instruments have become a standard which research investigators have relied on to understand the mechanisms of disease to combat cancer, in cells and tissues. The UMCCC Morphology Core offers these instruments to our Investigators on a shared use basis as a cost effective mechanism to investigate ongoing funded research projects.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Michigan Ann Arbor
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Verhaegen, Monique E; Mangelberger, Doris; Harms, Paul W et al. (2015) Merkel cell polyomavirus small T antigen is oncogenic in transgenic mice. J Invest Dermatol 135:1415-24
Chinn, Steven B; Darr, Owen A; Owen, John H et al. (2015) Cancer stem cells: mediators of tumorigenesis and metastasis in head and neck squamous cell carcinoma. Head Neck 37:317-26
Vainshtein, Jeffrey M; Spector, Matthew E; Stenmark, Matthew H et al. (2014) Reliability of post-chemoradiotherapy F-18-FDG PET/CT for prediction of locoregional failure in human papillomavirus-associated oropharyngeal cancer. Oral Oncol 50:234-9
Castro, Maria G; Candolfi, Marianela; Wilson, Thomas J et al. (2014) Adenoviral vector-mediated gene therapy for gliomas: coming of age. Expert Opin Biol Ther 14:1241-57
Vainshtein, Jeffrey M; Spector, Matthew E; McHugh, Jonathan B et al. (2014) Refining risk stratification for locoregional failure after chemoradiotherapy in human papillomavirus-associated oropharyngeal cancer. Oral Oncol 50:513-9
Grogan, Patrick T; Sarkaria, Jann N; Timmermann, Barbara N et al. (2014) Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation. Invest New Drugs 32:604-17
VanderVeen, Nathan; Paran, Christopher; Appelhans, Ashley et al. (2014) Marmosets as a preclinical model for testing "off-label" use of doxycycline to turn on Flt3L expression from high-capacity adenovirus vectors. Mol Ther Methods Clin Dev 1:
Krook, Melanie A; Nicholls, Lauren A; Scannell, Christopher A et al. (2014) Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma. Mol Cancer Res 12:953-64
Ro, Seung-Hyun; Semple, Ian A; Park, Haewon et al. (2014) Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J 281:3816-27
Stenmark, Matthew H; McHugh, Jonathan B; Schipper, Matthew et al. (2014) Nonendemic HPV-positive nasopharyngeal carcinoma: association with poor prognosis. Int J Radiat Oncol Biol Phys 88:580-8

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