The Experimental Irradiation core provides for the use of radiation by the members of the University of Michigan Comprehensive Cancer Center (UMCCC). The services of this core are critical to a variety of users in the UMCCC such as those Interested in radiation biology and radiation therapy, and those for whom radiation serves a research tool. Thus, it serves the goal of the Cancer Center to encourage basic research as well as translation and clinical applications. The irradiation core maintains and operates the irradiators and also consults with each investigator before initiation of a project, The experience and expertise of the director and manager allow them to offer Investigators Information on dosage and treatment regimens, particularly In animal studies, so that experimental resources are used In an optimal way. Another goal of the core is to foster Interactions between the users of the core by connecting investigators who have used radiation In various types of experiments over the last several years. Use of the Experimental Irradiation core by a variety of members of the Cancer Center is exemplified by the distribution of users. The 53 Cancer Center members who utilize the core participate In 10 Programs Including Breast Oncology, Cancer Cell Biology, Experimental Therapeutics, Gastrointestinal Oncology, and Radiation Sciences, among others. In order to provide this vital service, the core maintains 4 Irradiation devices. The 2 orthovoltage units (In the Medical Science I and Biomedical Science buildings) are used for irradiations of cell cultures and animals (primarily mice and rats but also available for use with rabbits and dogs). The core also maintains a small animal irradiator located In tine specific pathogen free area of the mouse housing in ULAM. The availability of this unit allows Investigators to perform Irradiations without removing immunodeficient mice from the quarantined facility. The fourth Irradiator Is for low dose rate (0.1-0.3 Gy/hour) irradiations. This irradiator, located within the Radiation Oncology department in the Medical Science I Building is built inside a humidified CO{2} Incubator, permitting studies of chronic exposure to very low radiation dose rates. The core is planning to expand Its services to also offer Cancer Center members the opportunity to Irradiate cell or DNA samples with ultraviolet light of different wavelengths.

Public Health Relevance

The Irradiation core maintains and operates the irradiators and also consults with each investigator before Initiation of a project. The experience and expertise of the director and manager allow them to offer investigators Information on dosage and treatment regimens, particularly In animal studies, so that experimental resources are used In an optimal way.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA046592-26
Application #
8696624
Study Section
Subcommittee B - Comprehensiveness (NCI)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
26
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Mendiratta-Lala, Mishal; Masch, William; Shankar, Prasad R et al. (2018) MR Imaging Evaluation of Hepatocellular Carcinoma Treated with Stereotactic Body Radiation Therapy (SBRT): Long Term Imaging Follow-Up. Int J Radiat Oncol Biol Phys :
Kim, Yeung-Hyen; Zhu, Lingqiao; Pyaram, Kalyani et al. (2018) PLZF-expressing CD4 T cells show the characteristics of terminally differentiated effector memory CD4 T cells in humans. Eur J Immunol 48:1255-1257
Davis, Elizabeth J; Griffith, Kent A; Kim, Edward J et al. (2018) A Phase II Study of Biweekly Cisplatin, Fixed-Dose-Rate Gemcitabine and Infusional 5-Fluorouracil in Patients With Metastatic Pancreatic and Biliary Cancers. Am J Clin Oncol 41:128-132
Rosselli-Murai, Luciana K; Yates, Joel A; Yoshida, Sei et al. (2018) Loss of PTEN promotes formation of signaling-capable clathrin-coated pits. J Cell Sci 131:
Tamura, Shuzo; Wang, Yin; Veeneman, Brendan et al. (2018) Molecular Correlates of In Vitro Responses to Dacomitinib and Afatinib in Bladder Cancer. Bladder Cancer 4:77-90
Mendiratta-Lala, Mishal; Gu, Everett; Owen, Dawn et al. (2018) Imaging Findings Within the First 12 Months of Hepatocellular Carcinoma Treated With Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys 102:1063-1069
Cilliers, Cornelius; Menezes, Bruna; Nessler, Ian et al. (2018) Improved Tumor Penetration and Single-Cell Targeting of Antibody-Drug Conjugates Increases Anticancer Efficacy and Host Survival. Cancer Res 78:758-768
Lorenz, Daniel A; Vander Roest, Steve; Larsen, Martha J et al. (2018) Development and Implementation of an HTS-Compatible Assay for the Discovery of Selective Small-Molecule Ligands for Pre-microRNAs. SLAS Discov 23:47-54
Zhou, Bing; Hu, Jiantao; Xu, Fuming et al. (2018) Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem 61:462-481
Cho, Chun-Seok; Park, Hwan-Woo; Ho, Allison et al. (2018) Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation. Hepatology 68:1331-1346

Showing the most recent 10 out of 1493 publications