The UCCC proposes three research Staff Investigators with particular focus in three strategic areas of UCCC development?metastasis and tumor-host microenvironment, cancer stem cell and regenerative medicine, and cancer survivorship. Each Staff Investigator will be responsible for overseeing the coordination, integration and development of research activities in their respective areas across the six Research Programs. Virginia Borges, MD, will serve in the role of Staff Investigator for metastasis and tumor-host microenvironment. She will be responsible for promoting the theme of tumor-host microenvironment interactions and how these affect tumor progression with a specific focus on metastasis across the programs, with the goal of building scientific collaborations to facilitate the development of a new Metastasis and Tumor Microenvironment (MTM) Program. Her research provides a paradigm and model of how immunologic and inflammatory cells promote metastasis, and as a practicing oncologist, she has the knowledge, experience and track record to take these findings to the clinic. Stephen Hunger, MD, will serve in the role of Staff Investigator for cancer stem cell and regenerative medicine. He will be responsible for promoting hematologic oncology research themes including transplantation and stem cell therapy across the programs, with an emphasis on building scientific collaborations to facilitate the development of a new Cancer Stem Cell Program. Dr. Hunger Is an internationally recognized leader in translational research and clinical trials related to childhood acute lymphoblastic leukemia (ALL), with over 100 peer-reviewed publications. Jean Kutner, MD will serve in the role of Staff Investigator for cancer survivorship and palliative care. She will be responsible for promoting survivorship and palliative care research themes across the programs, with an emphasis on building scientific collaborations to facilitate the development of a new Cancer Survivorship Program in the upcoming funding period. Her research in cancer survivorship issues, including late effects and palliative care, provides the appropriate background to oversee the efforts to develop a new survivorship program within the UCCC.

Public Health Relevance

Research Staff Investigators (SI) are important contributors to the programmatic and translational activities of the Cancer Center. The UCCC has 3 Si's in cancer immunology, pediatric oncology/stem cells and cancer survivorship to promote those research themes across the scientific programs and advance the development of new programs in the areas of Cancer Stem Cells, Metastasis and Tumor Microenvironment, and Cancer Survivorship.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Colorado Denver
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Harder, Bryan; Tian, Wang; La Clair, James J et al. (2017) Brusatol overcomes chemoresistance through inhibition of protein translation. Mol Carcinog 56:1493-1500
Chen, Yufei; Anastassiadis, Konstantinos; Kranz, Andrea et al. (2017) MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia. Cancer Cell 31:755-770.e6
DeRyckere, Deborah; Lee-Sherick, Alisa B; Huey, Madeline G et al. (2017) UNC2025, a MERTK Small-Molecule Inhibitor, Is Therapeutically Effective Alone and in Combination with Methotrexate in Leukemia Models. Clin Cancer Res 23:1481-1492
Scarborough, Hannah A; Helfrich, Barbara A; Casás-Selves, Matias et al. (2017) AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non-Small Cell Lung Cancer Cells Following EGFR Inhibition. Clin Cancer Res 23:1531-1541
Neelakantan, Deepika; Zhou, Hengbo; Oliphant, Michael U J et al. (2017) EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells. Nat Commun 8:15773
Barón, Anna E; Kako, Severine; Feser, William J et al. (2017) Clinical Utility of Chromosomal Aneusomy in Individuals at High Risk of Lung Cancer. J Thorac Oncol 12:1512-1523
Todd, Maria C; Langan, Thomas A; Sclafani, Robert A (2017) Doxycycline-Regulated p16MTS1 Expression Suppresses the Anchorage-Independence and Tumorigenicity of Breast Cancer Cell Lines that Lack Endogenous p16. J Cancer 8:190-198
Brown, Dustin G; Borresen, Erica C; Brown, Regina J et al. (2017) Heat-stabilised rice bran consumption by colorectal cancer survivors modulates stool metabolite profiles and metabolic networks: a randomised controlled trial. Br J Nutr 117:1244-1256
Haverkos, Bradley M; Abbott, Diana; Hamadani, Mehdi et al. (2017) PD-1 blockade for relapsed lymphoma post-allogeneic hematopoietic cell transplant: high response rate but frequent GVHD. Blood 130:221-228
Shearn, Colin T; Saba, Laura M; Roede, James R et al. (2017) Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH. Free Radic Biol Med 113:280-290

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