PEMT Service and the creation of CMOCO: The PEMT is derived from the previous Pathology Core, which focused on banking and histological services. The banking activities of the Pathology Core are now under the new Tissue Biobanking and Processing (TBP) Shared Resource. During the past funding period, it became evident that many users need molecular testing and many had no established testing laboratory to rely on. One such client was Dr. Wells Messersmith (DT), who needed KRAS testing colon cancers to be treated with Cetuximab. Because we were able to access and annotate tissue, we decided to expand our range of services and offer KRAS testing through the Core and a newly formed clinical laboratory, the Colorado Molecular Correlates (CMOCO). We were able to quickly standardize tissue block sampling and validate a rapid turn around (ARMS/Scorpions) assay (see Franklin et al, J Mol Diag., 2010) using Cancer Center support that we could then deploy in a large multicenter trial that is ongoing. The Service continues to be opportunistic in identifying correlative testing opportunities that support the other services of the Shared Resource and the clinical research activities of Cancer Center members as indicated in the discussion of lung cancer mutation consortium below.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Study Section
Subcommittee G - Education (NCI)
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University of Colorado Denver
United States
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Finlay-Schultz, J; Cittelly, D M; Hendricks, P et al. (2015) Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and Stat5a. Oncogene 34:3676-87
Alvarez-Calderon, Francesca; Gregory, Mark A; Pham-Danis, Catherine et al. (2015) Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations. Clin Cancer Res 21:1360-72
Kumar, Sushil; Raina, Komal; Agarwal, Chapla et al. (2014) Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals. Oncotarget 5:4972-89
Roth, Lauren W; Allshouse, Amanda A; Bradshaw-Pierce, Erica L et al. (2014) Luteal phase dynamics of follicle-stimulating and luteinizing hormones in obese and normal weight women. Clin Endocrinol (Oxf) 81:418-25
Roth, Lauren W; Bradshaw-Pierce, Erica L; Allshouse, Amanda A et al. (2014) Evidence of GnRH antagonist escape in obese women. J Clin Endocrinol Metab 99:E871-5
Colussi, Timothy M; Costantino, David A; Hammond, John A et al. (2014) The structural basis of transfer RNA mimicry and conformational plasticity by a viral RNA. Nature 511:366-9
Griesinger, Andrea M; Donson, Andrew M; Foreman, Nicholas K (2014) Immunotherapeutic implications of the immunophenotype of pediatric brain tumors. Oncoimmunology 3:e27256
Marek, Lindsay A; Hinz, Trista K; von Mässenhausen, Anne et al. (2014) Nonamplified FGFR1 is a growth driver in malignant pleural mesothelioma. Mol Cancer Res 12:1460-9
Holliday, Michael J; Zhang, Fengli; Isern, Nancy G et al. (2014) 1H, 13C, and 15N backbone and side chain resonance assignments of thermophilic Geobacillus kaustophilus cyclophilin-A. Biomol NMR Assign 8:23-7
Milgroom, Andrew; Intrator, Miranda; Madhavan, Krishna et al. (2014) Mesoporous silica nanoparticles as a breast-cancer targeting ultrasound contrast agent. Colloids Surf B Biointerfaces 116:652-7

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