PEMT Service and the creation of CMOCO: The PEMT is derived from the previous Pathology Core, which focused on banking and histological services. The banking activities of the Pathology Core are now under the new Tissue Biobanking and Processing (TBP) Shared Resource. During the past funding period, it became evident that many users need molecular testing and many had no established testing laboratory to rely on. One such client was Dr. Wells Messersmith (DT), who needed KRAS testing colon cancers to be treated with Cetuximab. Because we were able to access and annotate tissue, we decided to expand our range of services and offer KRAS testing through the Core and a newly formed clinical laboratory, the Colorado Molecular Correlates (CMOCO). We were able to quickly standardize tissue block sampling and validate a rapid turn around (ARMS/Scorpions) assay (see Franklin et al, J Mol Diag., 2010) using Cancer Center support that we could then deploy in a large multicenter trial that is ongoing. The Service continues to be opportunistic in identifying correlative testing opportunities that support the other services of the Shared Resource and the clinical research activities of Cancer Center members as indicated in the discussion of lung cancer mutation consortium below.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA046934-26
Application #
8616665
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
26
Fiscal Year
2014
Total Cost
$177,681
Indirect Cost
$61,331
Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
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