TISSUE BIOBANKING AND PROCESSING SHARED RESOURCE (Core-745) ABSTRACT Overview: The Tissue Biobanking and Processing Shared Resource (TBPSR) supports translational and clinical research projects of UCCC members by providing access to high-quality tissue and body fluid specimens that are associated with clinicopathologic and outcomes data. Equipment: The TBPSR has a wide variety of state of the art equipment for the procurement, processing, storage, and analysis of biospecimens. Services: The TBPSR provides services in three main areas 1) procurement, processing, archiving, and distribution of fresh and formalin-fixed tissues and body fluids, 2) specimen characterization, quality control, and linkage with pathological and clinical annotation, 3) special processing and auxiliary services including tissue microarray construction, laser capture microdissection and computer-assisted imaging/ image analysis. The TBPSR collaborates with the Cancer Clinical Trial Office and Health Data Compass to provide consents and detailed clinical and pathologic data correlated with distributed specimens. Consultation and Education: The TBPSR directors and staff consult with UCCC members to discuss protocol, project and grant development. The TBPSR directors provide educational sessions on biorepository and specimen management to researchers, students, and clinicians. Management: The TBPSR is a division of the larger Biorepository Core Facility, an institutional core managed by the institution. TBPSR is overseen by UCCC Associate Director for Population Sciences Research. Use of Services: Over the current funding period 64 UCCC members have used the services, representing all 6 Programs and resulting in 55 peer reviewed publications. CCSG funding represents 7% of the annual operating budget. The remaining support comes from the CCTSI grant (6%), other peer-reviewed grants (61%), institutional support (13%) and user fees (13%). Future Directions: The TBPSR proposes the following initiatives that will enhance the SR and UCCC member cancer research: 1) Implement the iLab system for management of the TBPSR; 2) Expand integration with the Health Data Compass. Compass is an integrated enterprise health data warehouse of all patient data obtained from consortium institutions (UCD, UCH, CHCO) which also provides analytic services designed to transform data-driven processes in clinical research, molecular discovery, and precision medicine; 3) Integrate with the Oncology Research Information Exchange Network (ORIEN), a consortium of academic medical centers utilizing a common protocol for tracking patient molecular, clinical and epidemiological data that follows the patient throughout his or her lifetime. This will expand the scope of the TBPSR locally and also help advance cancer research and care nationally.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA046934-30
Application #
9429057
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-02-01
Budget End
2019-01-31
Support Year
30
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Nemkov, Travis; Sun, Kaiqi; Reisz, Julie A et al. (2018) Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage. Haematologica 103:361-372
Soontararak, Sirikul; Chow, Lyndah; Johnson, Valerie et al. (2018) Mesenchymal Stem Cells (MSC) Derived from Induced Pluripotent Stem Cells (iPSC) Equivalent to Adipose-Derived MSC in Promoting Intestinal Healing and Microbiome Normalization in Mouse Inflammatory Bowel Disease Model. Stem Cells Transl Med 7:456-467
Shearn, Colin T; Pulliam, Casey F; Pedersen, Kim et al. (2018) Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet. Alcohol Clin Exp Res 42:1192-1205
Giles, Erin D; Jindal, Sonali; Wellberg, Elizabeth A et al. (2018) Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer. Breast Cancer Res 20:50
Wang, Guankui; Benasutti, Halli; Jones, Jessica F et al. (2018) Isolation of Breast cancer CTCs with multitargeted buoyant immunomicrobubbles. Colloids Surf B Biointerfaces 161:200-209
Suda, Kenichi; Kim, Jihye; Murakami, Isao et al. (2018) Innate Genetic Evolution of Lung Cancers and Spatial Heterogeneity: Analysis of Treatment-Naïve Lesions. J Thorac Oncol 13:1496-1507
Pennock, Nathan D; Martinson, Holly A; Guo, Qiuchen et al. (2018) Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer. J Immunother Cancer 6:98
Ross, Brian C; Boguslav, Mayla; Weeks, Holly et al. (2018) Simulating heterogeneous populations using Boolean models. BMC Syst Biol 12:64
Scott, Aaron J; Arcaroli, John J; Bagby, Stacey M et al. (2018) Cabozantinib Exhibits Potent Antitumor Activity in Colorectal Cancer Patient-Derived Tumor Xenograft Models via Autophagy and Signaling Mechanisms. Mol Cancer Ther 17:2112-2122
New, Melissa L; White, Collin M; McGonigle, Polly et al. (2018) Prostacyclin and EMT Pathway Markers for Monitoring Response to Lung Cancer Chemoprevention. Cancer Prev Res (Phila) 11:643-654

Showing the most recent 10 out of 1634 publications