Abstract

The Tissue and Research Pathology Services (TARPS) is an existing CCSG-funded shared facility that serves as the central support for UPCI research programs that utilize tissue materials from patients at the University of Pittsburgh Medical Center (UPMC). The main objectives of TARPS are to provide a mechanism to simplify and streamline the process of research tissue accrual and disbursement and to provide efficient research pathology support services. The tissue accrual and disbursement function of TARPS originated in 1991 as a small service facility, with a focus on genitourinary cancers. The resource has substantially expanded in the last 18 years and now procures and disburses tissue materials from patients with a diverse array of cancers, providing support to major research projects such as the Specialized Programs Of Research Excellence (SPORE) in Head and Neck, Lung, and Skin Cancers, the Early Disease Research Network (EDRN)-related research efforts, the Hematology-Oncology Service, and several other cancer research programs. Services provided by TARPS include: (1) tissue and biological specimen procurement, (2) research histology, (3) annotation of samples with clinical data, and (4) Tissue Micro-Array (TMA) facilities. Future efforts will include the development of procedures to molecularly profile tumors on a real-time basis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA047904-25
Application #
8519347
Study Section
Special Emphasis Panel (ZCA1-RTRB-L)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
25
Fiscal Year
2013
Total Cost
$159,650
Indirect Cost
$69,738

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Kumar, Dhruv; New, Jacob; Vishwakarma, Vikalp et al. (2018) Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression. Cancer Res 78:3769-3782
Weir, Mark C; Shu, Sherry T; Patel, Ravi K et al. (2018) Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo. ACS Chem Biol 13:1551-1559
Chakraborty, Souvik; Jiang, Chang; Gau, David et al. (2018) Profilin-1 deficiency leads to SMAD3 upregulation and impaired 3D outgrowth of breast cancer cells. Br J Cancer 119:1106-1117
Lu, Shanhong; Concha-Benavente, Fernando; Shayan, Gulidanna et al. (2018) STING activation enhances cetuximab-mediated NK cell activation and DC maturation and correlates with HPV+ status in head and neck cancer. Oral Oncol 78:186-193
Song, Xinxin; Lee, Dae-Hee; Dilly, Ashok-Kumar et al. (2018) Crosstalk Between Apoptosis and Autophagy Is Regulated by the Arginylated BiP/Beclin-1/p62 Complex. Mol Cancer Res 16:1077-1091
Chen, Dongshi; Tong, Jingshan; Yang, Liheng et al. (2018) PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. Proc Natl Acad Sci U S A 115:3930-3935
Teng, Yaqun; Yadav, Tribhuwan; Duan, Meihan et al. (2018) ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB. Nat Commun 9:4115
Nguyen, Nghi C; Yee, Melissa K; Tuchayi, Abuzar M et al. (2018) Targeted Therapy and Immunotherapy Response Assessment with F-18 Fluorothymidine Positron-Emission Tomography/Magnetic Resonance Imaging in Melanoma Brain Metastasis: A Pilot Study. Front Oncol 8:18
Hartmaier, R J; Trabucco, S E; Priedigkeit, N et al. (2018) Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer. Ann Oncol 29:872-880
Palliyaguru, Dushani L; Yuan, Jian-Min; Kensler, Thomas W et al. (2018) Isothiocyanates: Translating the Power of Plants to People. Mol Nutr Food Res 62:e1700965

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