The UCPI Biostatistics Facility (BF) provides statistical expertise in study design and data analysis for members of UPCI. This shared resource is cancer-center managed. Statisticians within the Facility collaborate on developing protocols for investigator-initiated clinical trials (IITs), and research plans and proposals for laboratory-based studies, population-science studies, and clinical investigations. Members of the Facility perform statistical analyses of data from these studies, substantively interpret results in collaboration with their UPCI colleagues, and author or co-author publications. Biostatistics personnel are involved extensively in cancer center-wide activities. These include participation at regular program meetings;service on UPCI committees for research oversight, protocol review, and data and safety monitoring;and collaborations with Clinical Research Services (CRS) and Cancer Informatics Services (CIS) to enhance UPCI operations and systems supporting IITs. Members of the Facility are active on review committees for the National Cancer Institute and as members of data and safety monitoring boards for the University of Pittsburgh Medical Center (UPMC). The Facility is also committed to developing statistical software for the design and analysis of laboratory-based studies and clinical trials that can be applied across multiple research programs and systems, such as that for patient registration and randomization, which can support UPCI IITs. The two guiding principles for the Facility are excellence in what we do and efficiency in accomplishing our work.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Special Emphasis Panel (ZCA1-RTRB-L)
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University of Pittsburgh
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Pollack, Ian F; Jakacki, Regina I; Butterfield, Lisa H et al. (2016) Antigen-specific immunoreactivity and clinical outcome following vaccination with glioma-associated antigen peptides in children with recurrent high-grade gliomas: results of a pilot study. J Neurooncol :
Concha-Benavente, Fernando; Srivastava, Raghvendra M; Trivedi, Sumita et al. (2016) Identification of the Cell-Intrinsic and -Extrinsic Pathways Downstream of EGFR and IFNγ That Induce PD-L1 Expression in Head and Neck Cancer. Cancer Res 76:1031-43
Posluszny, Donna M; Dew, Mary Amanda; Beckjord, Ellen et al. (2016) Existential challenges experienced by lymphoma survivors: Results from the 2010 LIVESTRONG Survey. J Health Psychol 21:2357-66
Vyas, Avani R; Moura, Michelle B; Hahm, Eun-Ryeong et al. (2016) Sulforaphane Inhibits c-Myc-Mediated Prostate Cancer Stem-Like Traits. J Cell Biochem 117:2482-95
Kirkwood, Caitlin M; MacDonald, Matthew L; Schempf, Tadhg A et al. (2016) Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration. J Neuropathol Exp Neurol 75:175-82
Chen, Mingqing; Sun, Fan; Han, Lei et al. (2016) Kaposi's sarcoma herpesvirus (KSHV) microRNA K12-1 functions as an oncogene by activating NF-κB/IL-6/STAT3 signaling. Oncotarget 7:33363-73
Gojo, Ivana; Beumer, Jan H; Pratz, Keith W et al. (2016) A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia. Clin Cancer Res :
Delgado, Evan; Boisen, Michelle M; Laskey, Robin et al. (2016) High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome. Gynecol Oncol 141:348-56
Rodler, Eve T; Kurland, Brenda F; Griffin, Melissa et al. (2016) Phase I Study of Veliparib (ABT-888) Combined with Cisplatin and Vinorelbine in Advanced Triple-Negative Breast Cancer and/or BRCA Mutation-Associated Breast Cancer. Clin Cancer Res 22:2855-64
Beumer, Jan H; Ding, Fei; Tawbi, Hussein et al. (2016) Effect of Renal Dysfunction on Toxicity in Three Decades of Cancer Therapy Evaluation Program-Sponsored Single-Agent Phase I Studies. J Clin Oncol 34:110-6

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