The Preclinical Imaging Research Laboratory (PIRL) is a shared resource of the Lombardi Comprehensive Cancer Center (Lombardi), formalized in 2006. The objective ofthe PIRL is to provide high-resolution in vivo small animal imaging and image analysis for Lombardi researchers involved in the study of cancer initiation, progression, and interdiction/therapy. The high-end instruments in PIRL enable noninvasive, longitudinal studies of cancer in vivo. The PIRL provides expertise in the design, acquisition, and analysis of preclinical imaging studies using the following instrumentation: a Bruker 7-Tesla magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) console, a small-animal ultrasound (Vevo660) workstation, an X-ray imaging unit (Faxltron) and a visible-near infrared spectroscopic imaging workstation (Maestro II). Support from the Lombardi in 2008 allowed the PIRL to acquire the Maestro workstation, update imaging software for the Bruker magnet to Paravision 4.0, and hire Dr. Yi-Chien Lee to perform the MR imaging. Additional upgrades to the magnet will be completed in May of 2009. The PIRL provides drop-off imaging, as well as training sessions for invesfigator initiated image acquisition. All original MRI and MRS data regardless of who has performed the acquisition are analyzed by the PIRL using Bruker software that is licensed to the PIRL. The director, Christopher Albanese, PhD, Associate Professor of Oncology, is a molecular biologist with expertise in genetically engineered mouse modeling and imaging. The PIRL is co-directed by John VanMeter, PhD, director of the ST human fMRI facility at Georgetown University Medical Center, with over 15 years of expertise in medical imaging and software development and Dr. Olga Rodriguez, MD, PhD, an Assistant Professor of Oncology and an expert in preclinical MRI as well as clinical and preclinical pathology. In 2008, the PIRL was utilized by 13 Lombardi investigators from four Lombardi programs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA051008-20
Application #
8739830
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-08-15
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
20
Fiscal Year
2013
Total Cost
$31,947
Indirect Cost
Name
Georgetown University
Department
Type
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Lai, Chih-Hsin; Lai, Ying-Jung J; Chou, Feng-Pai et al. (2016) Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation. PLoS One 11:e0152904
AlHossiny, Midrar; Luo, Linlin; Frazier, William R et al. (2016) Ly6E/K Signaling to TGFβ Promotes Breast Cancer Progression, Immune Escape, and Drug Resistance. Cancer Res 76:3376-86
Chung, Arlene E; Jensen, Roxanne E; Basch, Ethan M (2016) Leveraging Emerging Technologies and the "Internet of Things" to Improve the Quality of Cancer Care. J Oncol Pract 12:863-866
Brown, Lindsay; Gutherz, Samuel; Kulick, Catherine et al. (2016) Profile of retigabine-induced neuronal apoptosis in the developing rat brain. Epilepsia 57:660-70
Hunegnaw, Ruth; Vassylyeva, Marina; Dubrovsky, Larisa et al. (2016) Interaction Between HIV-1 Nef and Calnexin: From Modeling to Small Molecule Inhibitors Reversing HIV-Induced Lipid Accumulation. Arterioscler Thromb Vasc Biol 36:1758-71
Taylor, Kathryn L; Hoffman, Richard M; Davis, Kimberly M et al. (2016) Treatment Preferences for Active Surveillance versus Active Treatment among Men with Low-Risk Prostate Cancer. Cancer Epidemiol Biomarkers Prev 25:1240-50
Allen, Megan; Ghosh, Suhasini; Ahern, Gerard P et al. (2016) Protease induced plasticity: matrix metalloproteinase-1 promotes neurostructural changes through activation of protease activated receptor 1. Sci Rep 6:35497
Boca, Simina M; Nishida, Maki; Harris, Michael et al. (2016) Discovery of Metabolic Biomarkers for Duchenne Muscular Dystrophy within a Natural History Study. PLoS One 11:e0153461
Spikol, Emma D; Laverriere, Caroline E; Robnett, Maya et al. (2016) Zebrafish Models of Prader-Willi Syndrome: Fast Track to Pharmacotherapeutics. Diseases 4:
Cheema, Amrita K; Maier, Irene; Dowdy, Tyrone et al. (2016) Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis. PLoS One 11:e0151190

Showing the most recent 10 out of 883 publications