Flow Cytometry/Cell Sorting Shared Resource - Karen Creswell, PhD The Flow Cytometry/Cell Sorting Shared Resource (FCSR) was established in 1988 to provide flow cytometry support to researchers of the Lombardi Comprehensive Cancer Center. It has been supported by the CCSG since 1990 and is directed by Karen Creswell, PhD, who has been with the FCSR since 1991. The purpose of the FCSR is to use a wide range of flow cytometric and fluorescence-activated cell-sorting solutions for problems in cancer research. The FCSR provides comprehensive support of this technology in order to facilitate utillzation by a variety of investigators. Specifically, the FCSR: ? Maintains two flow cytometer/cell sorters that are the only instruments with cell sorting capability at Georgetown University; ? Provides trained operators to ensure efficient and correct use of this complex instrumentation and data interpretation; ? Provides personnel to assist with the application of a variety of fluorescence labeling methods; ? Provides expertise for the innovative application of this instrumentation to fully exploit the capabilities of this technology for cancer research. Since the last site visit, the FCSR's capabilities have been expanded by the addition of the FACSAria, purchased with a Shared Instrumentation Grant received by Dr. Creswell. In 2008, 37 peer-reviewed funded researchers from five Lombardi Comprehensive Cancer Center programs utilized FCSR services as an important tool in their research programs.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Georgetown University
United States
Zip Code
Bae, Woo Kyun; Yoo, Kyung Hyun; Lee, Ji Shin et al. (2015) The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancers. Mol Carcinog 54:1172-80
Adams, Inez; Christopher, Juleen; Williams, Karen Patricia et al. (2015) What Black Women Know and Want to Know About Counseling and Testing for BRCA1/2. J Cancer Educ 30:344-52
Butrick, Morgan; Kelly, Scott; Peshkin, Beth N et al. (2015) Disparities in uptake of BRCA1/2 genetic testing in a randomized trial of telephone counseling. Genet Med 17:467-75
London, Laricca; Hurtado-de-Mendoza, Alejandra; Song, Minna et al. (2015) Motivators and barriers to Latinas' participation in clinical trials: the role of contextual factors. Contemp Clin Trials 40:74-80
Mays, Darren; Niaura, Raymond S; Evans, W Douglas et al. (2015) Cigarette packaging and health warnings: the impact of plain packaging and message framing on young smokers. Tob Control 24:e87-92
Zhi, Xiuling; Lin, Ling; Yang, Shaoxian et al. (2015) ?II-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin. Hepatology 61:598-612
Rush, Christina L; Darling, Margaret; Elliott, Maria Gloria et al. (2015) Engaging Latina cancer survivors, their caregivers, and community partners in a randomized controlled trial: Nueva Vida intervention. Qual Life Res 24:1107-18
Heckler, Mary Mazzotta; Riggins, Rebecca B (2015) ERR? splice variants differentially regulate cell cycle progression. Cell Cycle 14:31-45
Kim, B; Wang, S; Lee, J M et al. (2015) Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy. Oncogene 34:1083-93
Tong, Angie; Kelly, Scott; Nusbaum, Rachel et al. (2015) Intentions for risk-reducing surgery among high-risk women referred for BRCA1/BRCA2 genetic counseling. Psychooncology 24:33-9

Showing the most recent 10 out of 544 publications