The Cancer Prevention and Control Program (CPC) represents a realignment of the former two population sciences programs (Cancer Control and Carcinogenesis, Biomarkers and Epidemiology). As the nexus for population science-focused research at Lombardi, the mission of CPC is to conduct population sciences research across the translational spectrum from discovery to interventions to policy. To accomplish this mission, we conduct research around four distinct themes and one cross-cutting theme. Theme 1 - Liver and Bladder Cancer focuses on investigation of environmental, genetic, and behavioral risks and biomarkers associated with liver and bladder cancer occurrence and early detection. Theme 2 - Translational Genomics focuses on investigations of cancer genetic/genomic risk testing to inform prevention, improve patient outcomes, and develop interventions to enhance clinical and policy translation. Theme 3 - Treatment and Survivorship focuses on cancer treatment and survivorship outcomes and the development of interventions to improve these outcomes. Theme 4 - Modeling focuses on population risk prediction and the impact of cancer control interventions to inform clinical practice and policy debates about the most effective and cost-effective care. In addition to these distinct themes. Cancer Disparities is a cross-cutting theme that is integrated within each ofthe four distinct programmatic foci. The program has 24 members, led by Marc Schwartz, PhD, and Christopher Loffredo, PhD, and includes faculty from 7 Departments and 2 institutions. Total direct funding is $11M in the last budget year, of which $6.7M is from the NCI (direct costs). Program members published 357 peer-reviewed publications during the current funding period of which 34% were intraprogrammatic, 22% were interprogrammatic and 63% involved external collaborators. Program members used all but one of the Shared Resources. The CPC addresses the cancer control needs of our catchment area through a strong research program focused on lifestyle, cancer-related behaviors, and health system factors. Research in the catchment area is facilitated through two community-based research sites! the Capital Breast Care Center and a new community-based center for disparities research and outreach located in Southeast DC. In addition to support of these community-based sites, Lombardi has added value to CPC through the recruitment and support of 12 new faculty members, investment in infrastructure, including laboratories, and support for biostatistics and bioinformatics.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA051008-21
Application #
8698911
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-08-15
Project End
2019-04-30
Budget Start
2014-09-09
Budget End
2015-04-30
Support Year
21
Fiscal Year
2014
Total Cost
$39,291
Indirect Cost
$14,023
Name
Georgetown University
Department
Type
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Bae, Woo Kyun; Yoo, Kyung Hyun; Lee, Ji Shin et al. (2015) The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancers. Mol Carcinog 54:1172-80
Adams, Inez; Christopher, Juleen; Williams, Karen Patricia et al. (2015) What Black Women Know and Want to Know About Counseling and Testing for BRCA1/2. J Cancer Educ 30:344-52
Butrick, Morgan; Kelly, Scott; Peshkin, Beth N et al. (2015) Disparities in uptake of BRCA1/2 genetic testing in a randomized trial of telephone counseling. Genet Med 17:467-75
London, Laricca; Hurtado-de-Mendoza, Alejandra; Song, Minna et al. (2015) Motivators and barriers to Latinas' participation in clinical trials: the role of contextual factors. Contemp Clin Trials 40:74-80
Mays, Darren; Niaura, Raymond S; Evans, W Douglas et al. (2015) Cigarette packaging and health warnings: the impact of plain packaging and message framing on young smokers. Tob Control 24:e87-92
Zhi, Xiuling; Lin, Ling; Yang, Shaoxian et al. (2015) ?II-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin. Hepatology 61:598-612
Rush, Christina L; Darling, Margaret; Elliott, Maria Gloria et al. (2015) Engaging Latina cancer survivors, their caregivers, and community partners in a randomized controlled trial: Nueva Vida intervention. Qual Life Res 24:1107-18
Heckler, Mary Mazzotta; Riggins, Rebecca B (2015) ERR? splice variants differentially regulate cell cycle progression. Cell Cycle 14:31-45
Kim, B; Wang, S; Lee, J M et al. (2015) Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy. Oncogene 34:1083-93
Tong, Angie; Kelly, Scott; Nusbaum, Rachel et al. (2015) Intentions for risk-reducing surgery among high-risk women referred for BRCA1/BRCA2 genetic counseling. Psychooncology 24:33-9

Showing the most recent 10 out of 544 publications