The overall mission of the Experimental Therapeutics Program (ET) is to reduce the cancer burden through preclinical and early clinical drug development, to determine optimal treatment approaches, combinations and sequences, and to identify prognostic, predictive and surrogate markers of efficacy and resistance for active agents. Theme 1 is focused on targeting known driver pathways of cancer. Significant accomplishments include trial using identification of mediators of drug resistance to EGFR pathway targeted drugs and application of findings in a clinical trial. Theme 2 is focused on targeting the tumor microenvironment. Significant accomplishments include combinations of immune modulatory or antiangiogenic drugs with pathway targeted inhibitors. Theme 3 is focused on developing novel drugs and biomarkers. Significant accomplishments include establishing an algorithm for repurposing of existing drugs for cancer indications and the generation of conditionally reprogrammed cells from patients'specimens for functional and drug sensitivity screening. Under new leadership, ET is now guided by Giuseppe Giaccone, MD, PhD, former Chief of the NCI Medical Oncology Branch and a leading expert in lung cancer and experimental therapeutics, and Anton Wellstein, MD, PhD, a pharmacologist whose translational research is focused on tumor stromal interactions and mechanisms of cancer progression to metastasis. ET has 26 members, including translational and clinical researchers, representing 11 departments at Georgetown University and one at MedStar Washington Hospital Center. The Program is supported by $3M in total peer reviewed direct funding ($1.SM in NCI funding) on total funding base of $6M. From 2009 to 2012, 19 investigator-initiated trials have accrued 380 patients. In this reporting period, ET members published 339 scholarly manuscripts;42% are intra- and/or interprogrammatic;the latter including publications with members of all three other LCCC Programs. About half of the publications (48%) involve external collaborations. ET members use all LCCC Shared Resources. The Program is organized by disease and modality groups to focus clinical research activities and prioritize clinical trials. The Cancer Center has added value to the Program by providing institutional support ($19M), recruiting leaders in the field that have enhanced ET's focus, breadth and depth (Giaccone, Atkins, Tan) and establishing the MedStar Georgetown Cancer Network to facilitate clinical research across MedStar institutions and better serve LCCC's catchment area

Public Health Relevance

Research focuses on cancers prevalent in LCCC's catchment area. The Program's commitment to increasing accrual to clinical trials, particularly among Black patients who are most affected in the catchment area, is essential. Furthermore, the expansion of ET trials to other institutions in the MedStar Georgetown Cancer Network is enhancing the availability of cutting-edge clinical research to patients in the catchment area.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA051008-21
Application #
8698912
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-08-15
Project End
2019-04-30
Budget Start
2014-09-09
Budget End
2015-04-30
Support Year
21
Fiscal Year
2014
Total Cost
$41,157
Indirect Cost
$14,689
Name
Georgetown University
Department
Type
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Bae, Woo Kyun; Yoo, Kyung Hyun; Lee, Ji Shin et al. (2015) The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancers. Mol Carcinog 54:1172-80
Adams, Inez; Christopher, Juleen; Williams, Karen Patricia et al. (2015) What Black Women Know and Want to Know About Counseling and Testing for BRCA1/2. J Cancer Educ 30:344-52
Butrick, Morgan; Kelly, Scott; Peshkin, Beth N et al. (2015) Disparities in uptake of BRCA1/2 genetic testing in a randomized trial of telephone counseling. Genet Med 17:467-75
London, Laricca; Hurtado-de-Mendoza, Alejandra; Song, Minna et al. (2015) Motivators and barriers to Latinas' participation in clinical trials: the role of contextual factors. Contemp Clin Trials 40:74-80
Mays, Darren; Niaura, Raymond S; Evans, W Douglas et al. (2015) Cigarette packaging and health warnings: the impact of plain packaging and message framing on young smokers. Tob Control 24:e87-92
Zhi, Xiuling; Lin, Ling; Yang, Shaoxian et al. (2015) ?II-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin. Hepatology 61:598-612
Rush, Christina L; Darling, Margaret; Elliott, Maria Gloria et al. (2015) Engaging Latina cancer survivors, their caregivers, and community partners in a randomized controlled trial: Nueva Vida intervention. Qual Life Res 24:1107-18
Heckler, Mary Mazzotta; Riggins, Rebecca B (2015) ERR? splice variants differentially regulate cell cycle progression. Cell Cycle 14:31-45
Kim, B; Wang, S; Lee, J M et al. (2015) Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy. Oncogene 34:1083-93
Tong, Angie; Kelly, Scott; Nusbaum, Rachel et al. (2015) Intentions for risk-reducing surgery among high-risk women referred for BRCA1/BRCA2 genetic counseling. Psychooncology 24:33-9

Showing the most recent 10 out of 544 publications