This application is to renew the NCI Cancer Center P30 Support Grant for the Cancer Therapy &Research Center (CTRC) at the University of Texas Health Science Center at San Antonio (UTHSCSA) for years 17-21. The CTRC at UTHSCSA merged with the formerly-independent CTRC to form this new entity (hereinafter called "CTRC"). This merger, in the form of a $150 million gift, the largest gift in UTHSCSA history, and among the largest in University of Texas history, brings full alignment to our Cancer Center activities. With this merger and realignment, the CTRC has re-entered a period of significant growth and improvement in the quality of its clinical, basic, translational and population-based research programs. Our NCI funding base has increased from $8,453,756 in 2006 to $11,050,146 in 2007. We serve a vast geographic region in and around San Antonio and South Texas, larger than the state of Pennsylvania and comprising 4.4 million inhabitants. Our population is predominantly Hispanic and dominated by individuals in lower socioeconomic strata with the lowest rates of health insurance coverage in the nation. We have worked to serve the disadvantaged for years, and are now also re-focusing more research and clinical efforts to understand better the specific cancer-related risks and disease patterns in Hispanics, and to serve the needs of our citizens better. We have significant community outreach, wellness and cancer screening programs reaching these disadvantaged populations. These efforts are greatly helped in that leaders in our Cancer Center and at UTHSCSA are Hispanic. We request support for three research programs, ten shared resources, seven senior leaders, one staff investigator, modest developmental funds, and commensurate administrative support. Our three research programs are Cancer Prevention and Population Sciences, Experimental and Developmental Therapeutics, and Cancer Development and Progression. Our shared resources are Antibody, Biostatistics and Informatics, Flow Cytometry, Genomics, Macromolecular Interactions, Macromolecular Structure, Mass Spectrometry, Optical Imaging, Pathology, and Research Administration. The CTRC will continue its record of promoting inter-programmatic and intra-programmatic collaborations, and strategic use of developmental funds, in combination with significant institutional commitment and a successful record of philanthropic support that in sum ensures a synergistic return on investment not possible without the P30 infrastructure and guidance.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA054174-19S6
Application #
8709458
Study Section
Subcommittee G - Education (NCI)
Program Officer
Shafik, Hasnaa
Project Start
1997-08-01
Project End
2014-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
19
Fiscal Year
2013
Total Cost
$75,000
Indirect Cost
$24,833
Name
University of Texas Health Science Center San Antonio
Department
Urology
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Ghosh, Sagar; Hughes, Daniel; Parma, Dorothy Long et al. (2014) Association of obesity and circulating adipose stromal cells among breast cancer survivors. Mol Biol Rep 41:2907-16
Meng, Jia; Lu, Zhiliang; Liu, Hui et al. (2014) A protocol for RNA methylation differential analysis with MeRIP-Seq data and exomePeak R/Bioconductor package. Methods 69:274-81
Gong, Jingjing; Muñoz, Amanda R; Chan, Daniel et al. (2014) STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth. Oncotarget 5:2529-41
Fok, Wilson C; Livi, Carolina; Bokov, Alex et al. (2014) Short-term rapamycin treatment in mice has few effects on the transcriptome of white adipose tissue compared to dietary restriction. Mech Ageing Dev 140:23-9
Morales, Liza D; Casillas Pavón, Edgar A; Shin, Jun Wan et al. (2014) Protein tyrosine phosphatases PTP-1B, SHP-2, and PTEN facilitate Rb/E2F-associated apoptotic signaling. PLoS One 9:e97104
Mousavi, Seyed Mohsen; Sundquist, Jan; Hemminki, Kari (2014) Risk of Kaposi sarcoma among immigrants to Sweden. Acta Derm Venereol 94:476-7
Ankerst, Donna P; Boeck, Andreas; Freedland, Stephen J et al. (2014) Evaluating the Prostate Cancer Prevention Trial High Grade Prostate Cancer Risk Calculator in 10 international biopsy cohorts: results from the Prostate Biopsy Collaborative Group. World J Urol 32:185-91
Biswas, Tanuka; Gu, Xiang; Yang, Junhua et al. (2014) Attenuation of TGF-* signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model. Cancer Lett 346:129-38
Ramirez, Amelie G; Munoz, Edgar; Holden, Alan E C et al. (2014) Incidence of hepatocellular carcinoma in Texas Latinos, 1995-2010: an update. PLoS One 9:e99365
Bansal, H; Yihua, Q; Iyer, S P et al. (2014) WTAP is a novel oncogenic protein in acute myeloid leukemia. Leukemia 28:1171-4

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