The Cancer Therapy &Research Center (CTRC) seeks renewal of its NCI designation originally awarded in 1991. The only academic Cancer Center in South Texas, the CTRC serves a large and predominantly Hispanic catchment area. The mission of the CTRC is to reduce the cancer burden in South Texas through the highest quality cancer care, ground-breaking research aimed at reducing the incidence and mortality of cancer, education of future cancer scientists and clinicians, and cancer prevention programs focused on our unique population. Dr. Ian M. Thompson, Jr., Director of the CTRC and the CTRC Senior Leaders have organized an interdisciplinary group of 78 cancer researchers (both basic and clinical) from two schools and 11 Departments within the UTHSCSA into three Programs: Cancer Development and Progression (CDP), Experimental and Developmental Therapeutics (EDT) and Cancer Prevention and Population Science (CPPS). These Programs are supported by 7 Shared Resources: Genomics, Next Generation Sequencing, Macromolecular Structure and Interactions, Mass Spectrometry, Flow Cytometry, Optical Imaging and Biostatistics. The CTRC also requests support for its Clinical Trials Office (CTO). Since 2008, improvements in the CTO have led to an increase in accruals, but importantly, an increase in interventional trials from 394 accruals in 2008 to 796 accruals in 2012. The CTRC has also made efforts to serve its catchment area illustrated by the fact that 46% of patients enrolled in interventional therapeutic clinical trials are Hispanic. Today, the UTHSCSA has $30,681,682M in annual total extramural research funding;a 74% increase from 2008. Of that $8,948,865M is from the NCI. Since 2008, 31 cancer-related clinical and research faculty have been recruited to the CTRC. All but one of the CTRC Senior Leaders are new since 2008. In 2011, UTHSCSA added 25,000 sq.ft. of CTRC-designated space in the new South Texas Research Facility, increasing CTRC-designated space to 285,193 sq.ft. The CTRC also invested in administrative infrastructure to support the CCSG and the research enterprise at the CTRC, in pilot funds for transdisciplinary research, and infrastructure to support clinical trials. The growth of the CTRC over the past 5 years is evidence of the commitment of the Center and its members to cancer research. Our members continue to make significant contributions to the cancer research field and develop novel approaches to prevent, diagnose and treat cancer, all with a continual focus on the predominantly Hispanic catchment area we serve.

Public Health Relevance

The Cancer Therapy &Research Center coordinates scientific research to promote interdisciplinary collaborations and translation of cancer research from the bench to bedside to community and provides outstanding shared research resources in support of its scientists, with the goal of reducing the cancer burden in South Texas.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA054174-20
Application #
8742346
Study Section
Special Emphasis Panel (ZCA1-RTRB-A (M3))
Program Officer
Shafik, Hasnaa
Project Start
1997-08-01
Project End
2019-07-31
Budget Start
2014-09-16
Budget End
2015-07-31
Support Year
20
Fiscal Year
2014
Total Cost
$1,800,000
Indirect Cost
$595,986
Name
University of Texas Health Science Center
Department
Urology
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Morales-Campos, Daisy Y; Vanderpool, Robin C (2017) Examining differences in HPV awareness and knowledge and HPV vaccine awareness and acceptability between U.S. Hispanic and island Puerto Rican women. J Health Dispar Res Pract 10:1-18
Elkashef, Sara M; Lin, An-Ping; Myers, Jamie et al. (2017) IDH Mutation, Competitive Inhibition of FTO, and RNA Methylation. Cancer Cell 31:619-620
Opp, Silvana; Fricke, Thomas; Shepard, Caitlin et al. (2017) The small-molecule 3G11 inhibits HIV-1 reverse transcription. Chem Biol Drug Des 89:608-618
Deng, Yilun; Flores, Shahida K; Cheng, ZiMing et al. (2017) Molecular and phenotypic evaluation of a novel germline TMEM127 mutation with an uncommon clinical presentation. Endocr Relat Cancer 24:L79-L82
Panneerdoss, Subbarayalu; Viswanadhapalli, Suryavathi; Abdelfattah, Nourhan et al. (2017) Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells. Nat Commun 8:598
Kim, Sun Kyung; Barron, Lindsey; Hinck, Cynthia S et al. (2017) An engineered transforming growth factor ? (TGF-?) monomer that functions as a dominant negative to block TGF-? signaling. J Biol Chem 292:7173-7188
Abbott, Jamie A; Guth, Ethan; Kim, Cindy et al. (2017) The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity. Biochemistry 56:3619-3631
Garza, John Anthony; Taylor, Alexander Bryan; Sherwood, Laura Jo et al. (2017) Unveiling a Drift Resistant Cryptotope within Marburgvirus Nucleoprotein Recognized by Llama Single-Domain Antibodies. Front Immunol 8:1234
Lee, Hak Joo; Lee, Doug Yoon; Mariappan, Meenalakshmi M et al. (2017) Hydrogen sulfide inhibits high glucose-induced NADPH oxidase 4 expression and matrix increase by recruiting inducible nitric oxide synthase in kidney proximal tubular epithelial cells. J Biol Chem 292:5665-5675
Katti, Sachin; Nyenhuis, Sarah B; Her, Bin et al. (2017) Non-Native Metal Ion Reveals the Role of Electrostatics in Synaptotagmin 1-Membrane Interactions. Biochemistry 56:3283-3295

Showing the most recent 10 out of 920 publications