The Cancer Prevention and Population Science (CPPS) Program conducts collaborative, hypothesis-driven and evidence-based, translational cancer prevention and control research that covers the cancer continuum primary prevention, early detection, laboratory research, clinical trials and applications, diagnosis and treatment, quality of life, and survivorship. Research in the CPPS Program is organized in a cancer control conceptual model that progresses from discovery to intervention to dissemination. The program has three scientific goals: 1) Identify determinants, biomarkers of risk and prognosis, genetics, and lifestyle factors to enhance cancer screening and treatment outcomes;2) Use laboratory-based molecular and experimental cancer prevention strategies to disrupt pathogenesis using synthetic and natural compounds, and lifestyle changes, translating preclinical evaluation of chemopreventive agents to interventional trials;and 3) Reduce the Latino cancer burden through community-based research, testing interventions addressing highly prevalent and disproportionate cancers and their risk factors in the Latino population. The 22 CPPS members include faculty from 11 academic departments and two schools at the University of Texas Health Science Center at San Antonio (UTHSCSA) and one at the University of Texas at San Antonio (UTSA). The CPPS Program has $7,154,300 in peer-revieyved cancer-related funding representing 30 peer-reviewed grants. Of this total, $2,438,763 (14 grants) are funded by the NCI. Over the last funding period, the CPPS Program has 186 peer-reviewed cancer related publications, of which 51 (28%) are intra-programmatic and 27 (15%) are inter-programmatic collaborations, with 78% of publications in collaboration with other institutions.
The Cancer Therapy &Research Center's Cancer Prevention and Population Science Program conducts collaborative, hypothesis-driven and evidence-based, translational cancer prevention and control research that covers the cancer continuum primary prevention, early detection, laboratory research, clinical trials and applications, diagnosis and treatment, quality of life, and survivorship, with a sustained focus on the CTRC catchment area.
|Newcomb, Lisa F; Thompson Jr, Ian M; Boyer, Hilary D et al. (2016) Outcomes of Active Surveillance for Clinically Localized Prostate Cancer in the Prospective, Multi-Institutional Canary PASS Cohort. J Urol 195:313-20|
|Zanotto-Filho, Alfeu; Dashnamoorthy, Ravi; Loranc, Eva et al. (2016) Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human. PLoS One 11:e0153970|
|Price, Douglas K; Chau, Cindy H; Till, Cathee et al. (2016) Association of androgen metabolism gene polymorphisms with prostate cancer risk and androgen concentrations: Results from the Prostate Cancer Prevention Trial. Cancer 122:2332-40|
|Ortiz, Carmen; Morales, Luisa; Sastre, Miguel et al. (2016) Cytotoxicity and Genotoxicity Assessment of Sandalwood Essential Oil in Human Breast Cell Lines MCF-7 and MCF-10A. Evid Based Complement Alternat Med 2016:3696232|
|Sareddy, Gangadhara R; Li, Xiaonan; Liu, Jinyou et al. (2016) Selective Estrogen Receptor Î² Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma. Sci Rep 6:24185|
|Zanotto-Filho, Alfeu; Masamsetti, V Pragathi; Loranc, Eva et al. (2016) Alkylating Agent-Induced NRF2 Blocks Endoplasmic Reticulum Stress-Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis. Mol Cancer Ther 15:3000-3014|
|Schenk, Jeannette M; Till, Cathee; Hsing, Ann W et al. (2016) Serum androgens and prostate cancer risk: results from the placebo arm of the Prostate Cancer Prevention Trial. Cancer Causes Control 27:175-82|
|Sweeney, Shannon R; Kavanaugh, Arthur; Lodi, Alessia et al. (2016) Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis. RMD Open 2:e000289|
|Wu, Anqi; Dong, Qiaoxiang; Gao, Hui et al. (2016) Characterization of mammary epithelial stem/progenitor cells and their changes with aging in common marmosets. Sci Rep 6:32190|
|Toledo, Rodrigo A; Qin, Yuejuan; Cheng, Zi-Ming et al. (2016) Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas. Clin Cancer Res 22:2301-10|
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