The Cancer Prevention and Population Science (CPPS) Program conducts collaborative, hypothesis-driven and evidence-based, translational cancer prevention and control research that covers the cancer continuum primary prevention, early detection, laboratory research, clinical trials and applications, diagnosis and treatment, quality of life, and survivorship. Research in the CPPS Program is organized in a cancer control conceptual model that progresses from discovery to intervention to dissemination. The program has three scientific goals: 1) Identify determinants, biomarkers of risk and prognosis, genetics, and lifestyle factors to enhance cancer screening and treatment outcomes;2) Use laboratory-based molecular and experimental cancer prevention strategies to disrupt pathogenesis using synthetic and natural compounds, and lifestyle changes, translating preclinical evaluation of chemopreventive agents to interventional trials;and 3) Reduce the Latino cancer burden through community-based research, testing interventions addressing highly prevalent and disproportionate cancers and their risk factors in the Latino population. The 22 CPPS members include faculty from 11 academic departments and two schools at the University of Texas Health Science Center at San Antonio (UTHSCSA) and one at the University of Texas at San Antonio (UTSA). The CPPS Program has $7,154,300 in peer-revieyved cancer-related funding representing 30 peer-reviewed grants. Of this total, $2,438,763 (14 grants) are funded by the NCI. Over the last funding period, the CPPS Program has 186 peer-reviewed cancer related publications, of which 51 (28%) are intra-programmatic and 27 (15%) are inter-programmatic collaborations, with 78% of publications in collaboration with other institutions.

Public Health Relevance

The Cancer Therapy &Research Center's Cancer Prevention and Population Science Program conducts collaborative, hypothesis-driven and evidence-based, translational cancer prevention and control research that covers the cancer continuum primary prevention, early detection, laboratory research, clinical trials and applications, diagnosis and treatment, quality of life, and survivorship, with a sustained focus on the CTRC catchment area.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA054174-20
Application #
8758355
Study Section
Special Emphasis Panel (ZCA1-RTRB-A (M3))
Project Start
1997-08-01
Project End
2019-07-31
Budget Start
2014-09-16
Budget End
2015-07-31
Support Year
20
Fiscal Year
2014
Total Cost
$58,464
Indirect Cost
$39,733
Name
University of Texas Health Science Center
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Du, Liqin; Zhao, Zhenze; Suraokar, Milind et al. (2018) LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer. Oncotarget 9:29601-29618
Ankerst, Donna P; Straubinger, Johanna; Selig, Katharina et al. (2018) A Contemporary Prostate Biopsy Risk Calculator Based on Multiple Heterogeneous Cohorts. Eur Urol 74:197-203
Sun, Xiujie; Gupta, Kshama; Wu, Bogang et al. (2018) Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulating adipose stromal interleukin 6 production in mice. J Biol Chem 293:2841-2849
Horning, Aaron M; Wang, Yao; Lin, Che-Kuang et al. (2018) Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle-Related Transcription and Attenuated Androgen Response. Cancer Res 78:853-864
Gong, Siqi; Tomusange, Khamis; Kulkarni, Viraj et al. (2018) Anti-HIV IgM protects against mucosal SHIV transmission. AIDS 32:F5-F13
Gelfond, Jonathan; Goros, Martin; Hernandez, Brian et al. (2018) A System for an Accountable Data Analysis Process in R. R J 10:6-21
Soteros, Breeanne M; Cong, Qifei; Palmer, Christian R et al. (2018) Sociability and synapse subtype-specific defects in mice lacking SRPX2, a language-associated gene. PLoS One 13:e0199399
Katti, Sachin; Her, Bin; Srivastava, Atul K et al. (2018) High affinity interactions of Pb2+ with synaptotagmin I. Metallomics 10:1211-1222
De La Chapa, Jorge J; Singha, Prajjal Kanti; Lee, Debbie R et al. (2018) Thymol inhibits oral squamous cell carcinoma growth via mitochondria-mediated apoptosis. J Oral Pathol Med 47:674-682
Wang, Zhonghua; Bhattacharya, Akash; White, Tommy et al. (2018) Functionality of Redox-Active Cysteines Is Required for Restriction of Retroviral Replication by SAMHD1. Cell Rep 24:815-823

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