The mission of the Mass Spectrometry Shared Resource (MSSR) is to provide Cancer Therapy &Research Center (CTRC) members and University of Texas Health Science Center (UTHSCSA) investigators with comprehensive, state-of-the-art support for characterization and quantification of proteins, metabolites and other biomedically important molecules using mass spectrometry. The MSSR has been in operation since 1979 and became a Cancer Center Shared Resource in 1998. There are two components of the MSSR, proteomics and metabolomics, which operate at two locations, a 713 sq. ft. space (Proteomics) on the Long (main) campus of the UTHSCSA and a 782 sq. ft. space (Metabolomics) on the Greehey (north) campus of the UTHSCSA in the South Texas Research Facility (STRF). The MSSR is jointly managed by the University and the CTRC. The MSSR services include molecular mass determination, protein identification, protein quantification, sequence characterization of peptides, localization covalent modification, and metabolomics (discovery experiments, targeted quantitative analysis, and small molecule analysis by GC-MS). The shared resource also offers consultations and training to CTRC investigators. The MSSR is directed by Susan Weintraub, Ph.D. The staff of the MSSR includes two-technical Directors, Kevin W. Hakala, M.S, (Proteomics) and Xiaoli Gao, Ph.D., (Metabolomics) with Sam Pardo as the Core Facilities Technologist. The MSSR team has expertise in the use of mass spectrometry to solve important cancer-related questions. During the last award year, the MSSR serviced 14 peer-review funded cancer center members, which comprised 19% of the total core users and contributed to 29 cancer-related peer-reviewed publications during the last funding period. Usage for the first half of 2013 increased two-fold, likely due to the addition of Metabolomics as a service.

Public Health Relevance

The MSSR supports CTRC investigators who are studying many different aspects of cancer related to fundamental processes, cancer metastasis, and cancer treatment. Analyses of proteins, peptides, small molecule metabolites, and candidate therapeutic agents are conducted by expert technical staff. These efforts provide essential information to elucidate mechanisms of cancer development and assess better ways to treat this deadly disease.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA054174-20
Application #
8934643
Study Section
Special Emphasis Panel (ZCA1-RTRB-A (M3))
Program Officer
Shafik, Hasnaa
Project Start
2014-09-16
Project End
2019-07-31
Budget Start
2014-09-16
Budget End
2015-07-31
Support Year
20
Fiscal Year
2014
Total Cost
$73,864
Indirect Cost
$39,732
Name
University of Texas Health Science Center
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
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