MOLECULAR BIOLOGY AND GENETICS OF CANCER PROGRAM The Molecular Biology and Genetics of Cancer Program integrates fundamental studies in the control of gene transcription with the genetic events and the molecular mechanisms underlying the most common types of hematological malignancies and solid tumors. An integral part of the KCC since 1991, this program focuses on gene discovery and gene function analyses. The long-term objective of this program is to exploit the translational potential of these studies for cancer diagnosis, prevention and therapy. The Molecular Biology and Genetics of Cancer Program is composed of 13 faculty members representing 5 different departments (including the Lankenau Institute for Medical Research). Several faculty members (Drs. Lisanti, McMahon, Nevalainen, O'Brien, Pascal, and Gilmour) are new recruits while most program members have been active in the KCC for many years. Program members are supported by NCI ($2.6 million) and other peer-reviewed grants ($9.8 million total peer-reviewed). They have 373 cancer-related publications, 13.5% of which are intra-programmatic and 19% are inter-programmatic. All faculty (except Drs. Gilmour and O'Brien) are housed in the Bluemle Life Sciences Building or Jefferson Alumni Hall. The program has 15-20 graduate students and more than 50 postdoctoral fellows. The program has monthly meetings to foster intra- and inter-programmatic interactions and to enhance its translational focus.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA056036-13
Application #
8378857
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
13
Fiscal Year
2012
Total Cost
$29,624
Indirect Cost
$10,380
Name
Thomas Jefferson University
Department
Type
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Mikkilineni, Lekha; Whitaker-Menezes, Diana; Domingo-Vidal, Marina et al. (2017) Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment. Semin Oncol 44:218-225
Wirblich, Christoph; Coleman, Christopher M; Kurup, Drishya et al. (2017) One-Health: a Safe, Efficient, Dual-Use Vaccine for Humans and Animals against Middle East Respiratory Syndrome Coronavirus and Rabies Virus. J Virol 91:
Weinberg, David S; Lin, Jieru E; Foster, Nathan R et al. (2017) Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention. Cancer Prev Res (Phila) 10:345-354
Monti, Daniel; Sotgia, Federica; Whitaker-Menezes, Diana et al. (2017) Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer. Semin Oncol 44:226-232
Curry, Joseph; Johnson, Jennifer; Tassone, Patrick et al. (2017) Metformin effects on head and neck squamous carcinoma microenvironment: Window of opportunity trial. Laryngoscope 127:1808-1815
Mitra, Ramkrishna; Chen, Xi; Greenawalt, Evan J et al. (2017) Decoding critical long non-coding RNA in ovarian cancer epithelial-to-mesenchymal transition. Nat Commun 8:1604
Paolillo, Carmela; Mu, Zhaomei; Rossi, Giovanna et al. (2017) Detection of Activating Estrogen Receptor Gene (ESR1) Mutations in Single Circulating Tumor Cells. Clin Cancer Res 23:6086-6093
Overmiller, Andrew M; Pierluissi, Jennifer A; Wermuth, Peter J et al. (2017) Desmoglein 2 modulates extracellular vesicle release from squamous cell carcinoma keratinocytes. FASEB J 31:3412-3424
Cheng, Hanyin; Chua, Vivian; Liao, Connie et al. (2017) Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma. Mol Cancer Ther 16:516-528
Jiang, Wei; Dulaimi, Essel; Devarajan, Karthik et al. (2017) Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma. Oncotarget 8:37423-37434

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