ENDOCRINE MECHANISMS AND HORMONE ACTION IN CANCER PROGRAM The Endocrine Mechanisms and Hormone Action in Cancer (EMHAC) Program is a new cancer center program, initiated in 2006. The overall goal of the program is to discover molecular alterations and signatures of hormone-related cancer and translate these findings into new strategies for effective detection, diagnosis, and cure. The program maintains a focus on translational. research on tumors arising from hormone-responsive tissues, including breast and prostate. Three program areas of focus include: 1) detection and diagnosis, 2) prognosis and progression, and 3) targets and therapy. The main specific Scientific Goals of the program are to: Develop innovative strategies and technologies for early detection of primary cancer and monitoring of therapy response and disease recurrence. Improve diagnostic tumor classification, prognostic and predictive marker analyses, and design of pre-clinical models for drug response prediction to facilitate improved tailored treatment. Exploit mechanisms of hormone action for molecular target identification, improved therapy, and prevention of hormone responsive cancer. Several collaborative initiatives are ongoing between the 15 members from 6 departments, supported by peer-reviewed funding of $4.2 million ($2.7 NCI) per year. An P01 program project grant proposal on breast cancer has been submitted from the program. Although this is a new program, several program members have worked collaboratively over many years, with more than 100 joint publications. Since the program's inception in 2006, there have been more than 20 intra-programmatic publications.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA056036-13
Application #
8378861
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
13
Fiscal Year
2012
Total Cost
$30,359
Indirect Cost
$10,637
Name
Thomas Jefferson University
Department
Type
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Ozaki, Shinji; Vuyyuru, Raja; Kageyama, Ken et al. (2016) Establishment and Characterization of Orthotopic Mouse Models for Human Uveal Melanoma Hepatic Colonization. Am J Pathol 186:43-56
Teh, Jessica L F; Purwin, Timothy J; Greenawalt, Evan J et al. (2016) An In Vivo Reporter to Quantitatively and Temporally Analyze the Effects of CDK4/6 Inhibitor-Based Therapies in Melanoma. Cancer Res 76:5455-66
Zhao, Yongtong; Shapiro, Sandor S; Eto, Masumi (2016) F-actin clustering and cell dysmotility induced by the pathological W148R missense mutation of filamin B at the actin-binding domain. Am J Physiol Cell Physiol 310:C89-98
Lu, Huimin; Wang, Tao; Li, Jing et al. (2016) αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor. Cancer Res 76:5163-74
Hutcheson, Jack; Balaji, Uthra; Porembka, Matthew R et al. (2016) Immunologic and Metabolic Features of Pancreatic Ductal Adenocarcinoma Define Prognostic Subtypes of Disease. Clin Cancer Res 22:3606-17
Singh, Amrita; Fedele, Carmine; Lu, Huimin et al. (2016) Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype. Mol Cancer Res 14:1136-1146
Zhao, Qian; Deng, Shengqiong; Wang, Guangxue et al. (2016) A direct quantification method for measuring plasma MicroRNAs identified potential biomarkers for detecting metastatic breast cancer. Oncotarget 7:21865-74
Pattison, Amanda M; Blomain, Erik S; Merlino, Dante J et al. (2016) Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins. Infect Immun 84:3083-91
Curry, Joseph M; Tassone, Patrick; Cotzia, Paolo et al. (2016) Multicompartment metabolism in papillary thyroid cancer. Laryngoscope 126:2410-8
Dowling, John P; Cai, Yubo; Bertin, John et al. (2016) Kinase-independent function of RIP1, critical for mature T-cell survival and proliferation. Cell Death Dis 7:e2379

Showing the most recent 10 out of 674 publications