For the next 5 year cycle of the Cancer Center Support Grant, the Kimmel Cancer Center is requesting approximately $400,000 per year in Developmental Funds. These funds are a critical source of flexible funding for the KCC, and provide a vital source of support for recruitment of new faculty and for pilot project funding. For the next cycle, all the funds requested will be utilized only for those purposes. Center-wide recruitment needs have been identified in four areas: Structural Biology, Radiation Research and Translational Biology, Genito-Urinary Cancer, and Cancer Genetics. Developmental Funds will enable recruitments in these areas, which will not only strengthen specific areas of need, but also enhance intra- and inter-programmatic collaborations. The pilot project funding initiative established in the previous cycle also will be continued with the support of Developmental Funds. During the previous cycle, Developmental Funds were used to support: 1) faculty recruitment, 2) establishment of new shared resources, and 3) support for pilot projects aimed at the submission of program project applications. The results of this funding have proven the expenditure of Developmental Funds to be very beneficial. New faculty recruited with and supported by Developmental Funds have been highly successful in establishing their laboratories, acquiring external, peer-reviewed funding, and starting to publish the results of their studies. Developmental Funds also enabled the establishment of two new shared resources (Microarray, and Proteomics and Mass Spectrometry) which have proven so invaluable to cancer center researchers that they will be transformed into full KCC shared resources in the next cycle. Numerous publications in top peer-reviewed journals have already resulted from the activities of these new shared resources. Developmental Funds also facilitated the recruitment of outstanding new Directors for both of these shared resources.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA056036-13
Application #
8378868
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
13
Fiscal Year
2012
Total Cost
$342,832
Indirect Cost
$120,123
Name
Thomas Jefferson University
Department
Type
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Peng, Weidan; Furuuchi, Narumi; Aslanukova, Ludmila et al. (2018) Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development. Mol Cell Biol 38:
Waldman, Scott A; Camilleri, Michael (2018) Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders. Gut 67:1543-1552
Sullivan-Reed, Katherine; Bolton-Gillespie, Elisabeth; Dasgupta, Yashodhara et al. (2018) Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells. Cell Rep 23:3127-3136
Lu, Huimin; Bowler, Nicholas; Harshyne, Larry A et al. (2018) Exosomal ?v?6 integrin is required for monocyte M2 polarization in prostate cancer. Matrix Biol 70:20-35
Lapadula, Dominic; Farias, Eduardo; Randolph, Clinita E et al. (2018) Effects of Oncogenic G?q and G?11 Inhibition by FR900359 in Uveal Melanoma. Mol Cancer Res :
Vite, Alexia; Zhang, Caimei; Yi, Roslyn et al. (2018) ?-Catenin-dependent cytoskeletal tension controls Yap activity in the heart. Development 145:
McNair, Christopher; Xu, Kexin; Mandigo, Amy C et al. (2018) Differential impact of RB status on E2F1 reprogramming in human cancer. J Clin Invest 128:341-358
Garcia, Samantha A; Lebrun, Aurore; Kean, Rhonda B et al. (2018) Clearance of attenuated rabies virus from brain tissues is required for long-term protection against CNS challenge with a pathogenic variant. J Neurovirol 24:606-615
Vido, Michael J; Le, Kaitlyn; Hartsough, Edward J et al. (2018) BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association. Cell Rep 25:1501-1510.e3
Brody, Jonathan R; Dixon, Dan A (2018) Complex HuR function in pancreatic cancer cells. Wiley Interdiscip Rev RNA 9:e1469

Showing the most recent 10 out of 807 publications