GASTROINTESTINAL CANCER PROGRAM The Gastrointestinal (Gl) Cancer Program was one of the original programs in Jefferson's Kimmel Cancer Center. It comprises sixteen cancer center faculty who represent eight departments within the School of Medicine (Anatomy, Cell Biology, and Pathology;Cancer Biology;Family Medicine;Internal Medicine; Medical Oncology;Radiology;and Pharmacology And Experimental Therapeutics;Surgery;) and the Christiana Care Health System (Helen F. Graham Cancer Center). Faculty hold appointments in five graduate programs in the School of Medicine (Cell Biology;Biochemistry;Genetics;Immunology;Molecular Pharmacology). Their work is supported by 4.4 million in peer-reviewed funding (3.7 million from NCI). In the last funding period, program members had 401 publications of which 5% are intra-programmmatic and 17% are inter-programmatic. The overarching goal of this multidisciplinary program is to define the fundamental mechanisms underlying Gl malignancies so that they may be translated into diagnostic and therapeutic innovations in managing cancer in patients and populations. Program members pursue parallel efforts organized vertically along organ-based disease processes and horizontally from discovery through translation and clinical development, to application. Members employ common and collaborative experimental paradigms with the goals of (1) defining previously unappreciated molecular, genetic, and epigenetic mechanisms underlying organ-based tumorigenesis, (2) translating defined mechanism-based components into novel in vitro and in vivo diagnostic tools that will enable early detection, prognosis, prediction, risk-stratification, and prevention in Gl malignancies, (3) exploiting novel mechanisms to define molecularly targeted therapeutic approaches for cancer prevention, treatment, and control, (4) advancing novel discoveries from program member laboratories into development as clinical trials, and (5) ultimately advancing diagnostic and therapeutic modalities which have been successful in clinical development into evidence-based practice for cancer prevention and control across populations. Members are interactive and cohesive. Under the direction of the program leader and co-leader, members coordinate planning, new research directions, and interactions with other research programs in the cancer center. Over the past 6 years, the faculty have gained momentum and built their reputation, reflecting remarkable innovation in disease diagnosis and management.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Thomas Jefferson University
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Ozaki, Shinji; Vuyyuru, Raja; Kageyama, Ken et al. (2016) Establishment and Characterization of Orthotopic Mouse Models for Human Uveal Melanoma Hepatic Colonization. Am J Pathol 186:43-56
Teh, Jessica L F; Purwin, Timothy J; Greenawalt, Evan J et al. (2016) An In Vivo Reporter to Quantitatively and Temporally Analyze the Effects of CDK4/6 Inhibitor-Based Therapies in Melanoma. Cancer Res 76:5455-66
Zhao, Yongtong; Shapiro, Sandor S; Eto, Masumi (2016) F-actin clustering and cell dysmotility induced by the pathological W148R missense mutation of filamin B at the actin-binding domain. Am J Physiol Cell Physiol 310:C89-98
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Zhao, Qian; Deng, Shengqiong; Wang, Guangxue et al. (2016) A direct quantification method for measuring plasma MicroRNAs identified potential biomarkers for detecting metastatic breast cancer. Oncotarget 7:21865-74
Pattison, Amanda M; Blomain, Erik S; Merlino, Dante J et al. (2016) Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins. Infect Immun 84:3083-91
Curry, Joseph M; Tassone, Patrick; Cotzia, Paolo et al. (2016) Multicompartment metabolism in papillary thyroid cancer. Laryngoscope 126:2410-8
Dowling, John P; Cai, Yubo; Bertin, John et al. (2016) Kinase-independent function of RIP1, critical for mature T-cell survival and proliferation. Cell Death Dis 7:e2379

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