GASTROINTESTINAL CANCER PROGRAM The Gastrointestinal (Gl) Cancer Program was one of the original programs in Jefferson's Kimmel Cancer Center. It comprises sixteen cancer center faculty who represent eight departments within the School of Medicine (Anatomy, Cell Biology, and Pathology;Cancer Biology;Family Medicine;Internal Medicine; Medical Oncology;Radiology;and Pharmacology And Experimental Therapeutics;Surgery;) and the Christiana Care Health System (Helen F. Graham Cancer Center). Faculty hold appointments in five graduate programs in the School of Medicine (Cell Biology;Biochemistry;Genetics;Immunology;Molecular Pharmacology). Their work is supported by 4.4 million in peer-reviewed funding (3.7 million from NCI). In the last funding period, program members had 401 publications of which 5% are intra-programmmatic and 17% are inter-programmatic. The overarching goal of this multidisciplinary program is to define the fundamental mechanisms underlying Gl malignancies so that they may be translated into diagnostic and therapeutic innovations in managing cancer in patients and populations. Program members pursue parallel efforts organized vertically along organ-based disease processes and horizontally from discovery through translation and clinical development, to application. Members employ common and collaborative experimental paradigms with the goals of (1) defining previously unappreciated molecular, genetic, and epigenetic mechanisms underlying organ-based tumorigenesis, (2) translating defined mechanism-based components into novel in vitro and in vivo diagnostic tools that will enable early detection, prognosis, prediction, risk-stratification, and prevention in Gl malignancies, (3) exploiting novel mechanisms to define molecularly targeted therapeutic approaches for cancer prevention, treatment, and control, (4) advancing novel discoveries from program member laboratories into development as clinical trials, and (5) ultimately advancing diagnostic and therapeutic modalities which have been successful in clinical development into evidence-based practice for cancer prevention and control across populations. Members are interactive and cohesive. Under the direction of the program leader and co-leader, members coordinate planning, new research directions, and interactions with other research programs in the cancer center. Over the past 6 years, the faculty have gained momentum and built their reputation, reflecting remarkable innovation in disease diagnosis and management.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA056036-13
Application #
8378870
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
13
Fiscal Year
2012
Total Cost
$30,359
Indirect Cost
$10,637
Name
Thomas Jefferson University
Department
Type
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Mikkilineni, Lekha; Whitaker-Menezes, Diana; Domingo-Vidal, Marina et al. (2017) Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment. Semin Oncol 44:218-225
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Paolillo, Carmela; Mu, Zhaomei; Rossi, Giovanna et al. (2017) Detection of Activating Estrogen Receptor Gene (ESR1) Mutations in Single Circulating Tumor Cells. Clin Cancer Res 23:6086-6093
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Cheng, Hanyin; Chua, Vivian; Liao, Connie et al. (2017) Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma. Mol Cancer Ther 16:516-528
Jiang, Wei; Dulaimi, Essel; Devarajan, Karthik et al. (2017) Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma. Oncotarget 8:37423-37434

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