Since the inception of the Translational Research Shared Resource its mission has been to provide tissue processing, slide preparation, histochemical staining, and immunohistochemical staining for human neoplastic tissue and experimental animal model tissue being utilized by KCC researchers. This shared resource has also provided procurement, banking and distribution of human neoplastic tissue in order to facilitate translational research. The caBlG caTissue biospecimen management application has been used by tissue bankers since 2007 to enter clinical and pathogical specimen annotation, as well as track specimen storage and distribution. This biospecimen database integrates access to 7 campus specimen collections having about 440,000 specimens from 170,000 individuals. In addition, the Translational Research Shared Resource provides tissue microarrays construction service with paraffin archive material from the resource tumor/tissue bank. Laser microdissection of distinct cell and tissue types for molecular analysis can be performed on the resource's Laser Microdissection system. For all of the capabilities offered by the Translational Research Shared Resource, staff is available to provide technical support and pathology expertise to KCC investigators. Between 2008 and 2011 23 principal investigators from all programs of the KCC benefited from this shared resource.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Thomas Jefferson University
United States
Zip Code
Li, Jifen; Gao, Erhe; Vite, Alexia et al. (2015) Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity. Circ Res 116:70-9
Basile, Kevin J; Le, Kaitlyn; Hartsough, Edward J et al. (2014) Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors. Pigment Cell Melanoma Res 27:479-84
Sonar, Mahesh V; Wampole, Matthew E; Jin, Yuan-Yuan et al. (2014) Fluorescence detection of KRAS2 mRNA hybridization in lung cancer cells with PNA-peptides containing an internal thiazole orange. Bioconjug Chem 25:1697-708
Gu, Lei; Talati, Pooja; Vogiatzi, Paraskevi et al. (2014) Pharmacologic suppression of JAK1/2 by JAK1/2 inhibitor AZD1480 potently inhibits IL-6-induced experimental prostate cancer metastases formation. Mol Cancer Ther 13:1246-58
Bhardwaj, Anshul; Casjens, Sherwood R; Cingolani, Gino (2014) Exploring the atomic structure and conformational flexibility of a 320?Å long engineered viral fiber using X-ray crystallography. Acta Crystallogr D Biol Crystallogr 70:342-53
Siciliano, Nicholas A; Hersperger, Adam R; Lacuanan, Aimee M et al. (2014) Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses. J Virol 88:10078-91
Clark, Peter M; Loher, Phillipe; Quann, Kevin et al. (2014) Argonaute CLIP-Seq reveals miRNA targetome diversity across tissue types. Sci Rep 4:5947
Li, Yuan; Liang, Chunli; Ma, Haizhong et al. (2014) miR-221/222 promotes S-phase entry and cellular migration in control of basal-like breast cancer. Molecules 19:7122-37
Wilson, Chantell; Lin, Jieru E; Li, Peng et al. (2014) The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer. Cancer Epidemiol Biomarkers Prev 23:2328-37
Khasnis, Mukta; Nakatomi, Akiko; Gumpper, Kristyn et al. (2014) Reconstituted human myosin light chain phosphatase reveals distinct roles of two inhibitory phosphorylation sites of the regulatory subunit, MYPT1. Biochemistry 53:2701-9

Showing the most recent 10 out of 343 publications