DESCRIPTION OF SHARED RESOURCE The Biostatistics Shared Resource (BSR) consists of partial effort from six PhD-level faculty biostatisticians and six MS-level or higher technical support staff to collaborate and consult with Kimmel Cancer Center investigators in the design, conduct, and analysis of cancer-related clinical, translational and scientific investigations, and to review clinical trial proposals for cancer-related studies within the Cancer Clinical Research Review Committee (CCRRC). The Division of Biostatistics consists of six PhD faculty, 2 PhD technical senior staff, and 4 MS-level staff, all participate at least partial effort to cancer research, but the Division also serves as the research resource for the entire University. The BSR provides consultation and expertise regarding study design (including validity of the overall design, feasibility of meeting objectives, sample size, study duration, and planned data analysis), recommendations for staffing (data management and analysis support), data analysis, preparation of reports and assistance with manuscript writing, and development of new biostatistical methods, when applicable. The general goal of the BSR is to ensure that study designs, monitoring, and analyses use state-of-the-art methods, and to help developmental studies supported by the Center successfully achieve peer reviewed funding. The BSR has experienced growth during the recent grant cycle, particularly by adding faculty and staff with mathematical programming and robust methods expertise. Plans for the future of Biostatistics include continued growth to meet the needs of the KCC, development in key areas including clinical trials design, and continued strength in methodological development that informs cancer research. The Biostatistics Shared Facility was used by 49 KCC members.
Members of the Biostatistics Shared Resource (BSR) partner with cancer center investigators to design studies, write sections of grant applications related to study design and analysis techniques, participate in study planning and management meetings, complete data analysis, and write manuscripts for the scientific literature reporting findings. BSR faculty and staff have expertise in computational methods.
|Li, Jifen; Gao, Erhe; Vite, Alexia et al. (2015) Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity. Circ Res 116:70-9|
|Basile, Kevin J; Le, Kaitlyn; Hartsough, Edward J et al. (2014) Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors. Pigment Cell Melanoma Res 27:479-84|
|Sonar, Mahesh V; Wampole, Matthew E; Jin, Yuan-Yuan et al. (2014) Fluorescence detection of KRAS2 mRNA hybridization in lung cancer cells with PNA-peptides containing an internal thiazole orange. Bioconjug Chem 25:1697-708|
|Gu, Lei; Talati, Pooja; Vogiatzi, Paraskevi et al. (2014) Pharmacologic suppression of JAK1/2 by JAK1/2 inhibitor AZD1480 potently inhibits IL-6-induced experimental prostate cancer metastases formation. Mol Cancer Ther 13:1246-58|
|Bhardwaj, Anshul; Casjens, Sherwood R; Cingolani, Gino (2014) Exploring the atomic structure and conformational flexibility of a 320?Å long engineered viral fiber using X-ray crystallography. Acta Crystallogr D Biol Crystallogr 70:342-53|
|Siciliano, Nicholas A; Hersperger, Adam R; Lacuanan, Aimee M et al. (2014) Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses. J Virol 88:10078-91|
|Clark, Peter M; Loher, Phillipe; Quann, Kevin et al. (2014) Argonaute CLIP-Seq reveals miRNA targetome diversity across tissue types. Sci Rep 4:5947|
|Li, Yuan; Liang, Chunli; Ma, Haizhong et al. (2014) miR-221/222 promotes S-phase entry and cellular migration in control of basal-like breast cancer. Molecules 19:7122-37|
|Wilson, Chantell; Lin, Jieru E; Li, Peng et al. (2014) The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer. Cancer Epidemiol Biomarkers Prev 23:2328-37|
|Khasnis, Mukta; Nakatomi, Akiko; Gumpper, Kristyn et al. (2014) Reconstituted human myosin light chain phosphatase reveals distinct roles of two inhibitory phosphorylation sites of the regulatory subunit, MYPT1. Biochemistry 53:2701-9|
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