The Robert H. Lurie Comprehensive Cancer Center of Northwestern University is an NCI-designated, university-based, matrix Cancer Center conducting a broad range of multidisciplinary clinical, laboratory and population science research. The Cancer Center integrates the expertise and resources of the Feinberg School of Medicine (Chicago Campus) and its affiliated hospitals along with those of departments located on the University's Evanston Campus. Established in 1974, the Cancer Center functions as a full organizational unit with the status of a department of the Medical School. Since its inception, the Cancer Center has been dedicated to the process of discovery, advancing medical knowledge and providing compassionate, state-of-the-art cancer care, as reflected in the following goals: 1. To conduct and support cancer research and to integrate cancer-related research throughout the University; 2. To coordinate and integrate cancer-related activities of the University including community outreach initiatives; 3. To develop and conduct cancer education programs; 4. To promote and participate in state-of-the-art care of cancer patients at the affiliated hospitals of the McGaw Medical Center of Northwestern University;and 5. To develop and implement initiatives in cancer prevention and control research. These goals are accomplished through the activities of 10 established programs and 13 shared resources. Programs 1. Viral Oncogenesis 2. Tumor Invasion, Metastasis, &Angiogenesis 3. Hormone Action/Signal Transduction in Cancer 4. Cancer Genes and Molecular Targeting 5. Cancer Cell Biology 6. Breast Cancer 7. Prostate Cancer 8. Hematologic Malignancies 9. Cancer Prevention 10. Cancer Control Shared Resources 1. Cell Imaging 2. Flow Cytometry 3. Genomics Core 4. Keck Biophysics 5. Monoclonal Antibody 6. Mouse Phenotyping 7. Pathology Core 8. Structural Biology 9. Transgenic and Targeted Mutagenesis Laboratory 10. Outcomes Measurement &Survey Core 11. Bioinformatics Core 12. Biostatistics Core 13. Clinical Research Office This competing renewal application is being submitted as a Partnership Application with two of the Cancer Center's affiliated hospitals, Evanston Northwestern Healthcare and Children's Memorial Hospital. The Cancer Center members at the Partner institutions are fully integrated with those at the main campuses of the University, and together, contribute to the ongoing progress of the Center in achieving its mission, goals and objectives.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA060553-18S3
Application #
8486506
Study Section
Subcommittee G - Education (NCI)
Program Officer
Ptak, Krzysztof
Project Start
1997-08-01
Project End
2013-07-31
Budget Start
2012-09-06
Budget End
2013-07-31
Support Year
18
Fiscal Year
2012
Total Cost
$4,829,857
Indirect Cost
$1,703,736
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Hong, Bong Jin; Iscen, Aysenur; Chipre, Anthony J et al. (2018) Highly Stable, Ultrasmall Polymer-Grafted Nanobins (usPGNs) with Stimuli-Responsive Capability. J Phys Chem Lett 9:1133-1139
Smith, Erica D; Garza-Gongora, Arturo G; MacQuarrie, Kyle L et al. (2018) Interstitial telomeric loops and implications of the interaction between TRF2 and lamin A/C. Differentiation 102:19-26
Hsiao, Hsi-Min; Fernandez, Ramiro; Tanaka, Satona et al. (2018) Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1?. J Clin Invest 128:2833-2847
Mehta, Amol; Awah, Chidiebere U; Sonabend, Adam M (2018) Topoisomerase II Poisons for Glioblastoma; Existing Challenges and Opportunities to Personalize Therapy. Front Neurol 9:459
Brown, Jessica H; Das, Prativa; DiVito, Michael D et al. (2018) Nanofibrous PLGA electrospun scaffolds modified with type I collagen influence hepatocyte function and support viability in vitro. Acta Biomater 73:217-227
Ntai, Ioanna; Fornelli, Luca; DeHart, Caroline J et al. (2018) Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk. Proc Natl Acad Sci U S A 115:4140-4145
Wiwatpanit, Teerawat; Remis, Natalie N; Ahmad, Aisha et al. (2018) Codeficiency of Lysosomal Mucolipins 3 and 1 in Cochlear Hair Cells Diminishes Outer Hair Cell Longevity and Accelerates Age-Related Hearing Loss. J Neurosci 38:3177-3189
Malik, Neha; Iyamu, Iredia D; Scheidt, Karl A et al. (2018) Synthesis of a novel fused pyrrolodiazepine-based library with anti-cancer activity. Tetrahedron Lett 59:1513-1516
Wong, Yvette C; Ysselstein, Daniel; Krainc, Dimitri (2018) Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis. Nature 554:382-386
Ladomersky, Erik; Zhai, Lijie; Lenzen, Alicia et al. (2018) IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma. Clin Cancer Res 24:2559-2573

Showing the most recent 10 out of 1972 publications