The Pathology Core Facility of the Robert H. Lurie Comprehensive Cancer Center provides pathological analysis and specimen procurement, processing and distribution services to the NU research community. Pathological analysis in the past was mostly limited to routine tissue processing, staining and a limited panel of immunohistochemical stains. Today, pathological analysis in cancer research involves more sophisticated testing, including high-throughput tissue microarray generation, novel immunohistochemistry, in situ hybridization, or digital imaging analysis for the objective assessment of tissue based assays. Similarly, specimen procurement, processing and distribution are increasingly more sophisticated today. Cancer researchers now require technologies such as DNA/RNA/mRNA extraction, generation of cell monolayers from body fluids, laser capture microdissection, isolation of circulating tumor cells, and other technologies to address cancer-related questions. An exciting development in cancer care in the past few years is the use of targeted therapies and the sub-stratification of patients into more precise treatment groups. Examples include her2/neu testing by FISH or IHC in breast cancer, thymidylate synthase testing in colon cancer, MSI testing in colon cancer, c-kit testing in a variety of tumors, pharmacogenomics and others. Other examples of these """"""""cutting-edge"""""""" approaches to cancer research are presented throughout this grant. The PCF is fortunate to be at the forefront of these exciting developments in cancer care in its capacity as the Reference Laboratory for the Eastern Cooperative Oncology Group. Continued funding of the PCF infrastructure will allow it to continue to meet the growing and increasingly complex needs of cancer patients and cancer researchers.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Northwestern University at Chicago
United States
Zip Code
Kaluzny, Joel; Purta, Patryk; Poskin, Zach et al. (2016) Ex Vivo Confocal Spectroscopy of Autofluorescence in Age-Related Macular Degeneration. PLoS One 11:e0162869
Marsh, Erica E; Chibber, Shani; Wu, Ju et al. (2016) Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 expression and regulation in uterine leiomyoma. Fertil Steril 105:1070-5
Zhao, Baobing; Mei, Yang; Schipma, Matthew J et al. (2016) Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening. Dev Cell 36:498-510
Ridge, Karen M; Shumaker, Dale; Robert, Amélie et al. (2016) Methods for Determining the Cellular Functions of Vimentin Intermediate Filaments. Methods Enzymol 568:389-426
White, Sarah Beth; Procissi, Daniele; Chen, Jeane et al. (2016) Characterization of CC-531 as a Rat Model of Colorectal Liver Metastases. PLoS One 11:e0155334
Zhao, J C; Fong, K-W; Jin, H-J et al. (2016) FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression. Oncogene 35:4335-44
Isabella, Adam J; Horne-Badovinac, Sally (2016) Rab10-Mediated Secretion Synergizes with Tissue Movement to Build a Polarized Basement Membrane Architecture for Organ Morphogenesis. Dev Cell 38:47-60
Valdovinos, Cristina; Penedo, Frank J; Isasi, Carmen R et al. (2016) Perceived discrimination and cancer screening behaviors in US Hispanics: the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study. Cancer Causes Control 27:27-37
Quinn, Gwendolyn P; Woodruff, Teresa K; Knapp, Caprice A et al. (2016) Expanding the Oncofertility Workforce: Training Allied Health Professionals to Improve Health Outcomes for Adolescents and Young Adults. J Adolesc Young Adult Oncol 5:292-6
Sun, Jun; Xing, Zhaoyu; Xing, Wei et al. (2016) Intratumoral Macroscopic Fat and Hemorrhage Combination Useful in the Differentiation of Benign and Malignant Solid Renal Masses. Medicine (Baltimore) 95:e2960

Showing the most recent 10 out of 1027 publications