The Keck Biophysics Facility is a center for molecular biophysical research which provides Northwestern groups with advanced equipment outstanding services, specialized training, and technical expertise. Created in 1998 by Northwestern University's Center for Structural Biology with a grant from the W.M. Keck Foundation and additional support from the NIH, the Rice Foundation, and the Robert H. Lurie Comprehensive Cancer Center (RHLCCC), Keck has been one of Northwestern's Shared Resources since April 1,1999. The Keck Facility has a set of 20 advanced instruments that together allow for integrated biophysical analyses of macromolecular structure, interactions, and function. Each particular biophysical instrument, such as a circular dichroism spectrometer, a fluorimeter, or a calorimeter, provides just one or a few individual facets of a complex overall picture. Data from many individual biophysical studies - using a diverse set of particular instruments - must be combined to yield the needed comprehensive picture. In the past 5 years, the facility has been thoroughly modernized with state of the art equipment that replaced older instruments, addition of new technologies and capabilities, a modern internet-based reservation/administration system and many upgrades. In parallel, the Facility has invested in personnel training in order to provide users with outstanding technical expertise and assistance. To better accommodate the needs of our diverse user base, we are offering a flexible array of services. Besides counseling, training and assistance, full service options are also available on all the Facility's instruments. The Keck Facility currently has 506 active users from 90 research groups (students, postdoctoral fellows, and faculty who are authorized to use Keck Facility equipment). Researchers affiliated with the RHLCCC account for over 80% of the total utilization ofthe Facility. As such, the Keck Biophysics Facility is a critical resource for cancer research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA060553-20
Application #
8761067
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
20
Fiscal Year
2014
Total Cost
$147,627
Indirect Cost
$52,811
Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Yang, Ruiguo; LemaƮtre, Vincent; Huang, Changjin et al. (2018) Monoclonal Cell Line Generation and CRISPR/Cas9 Manipulation via Single-Cell Electroporation. Small 14:e1702495
Buglak, Nicholas E; Jiang, Wulin; Bahnson, Edward S M (2018) Cinnamic aldehyde inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in Zucker Diabetic Fatty rats. Redox Biol 19:166-178
Takahashi, Satoe; Sun, Willy; Zhou, Yingjie et al. (2018) Prestin Contributes to Membrane Compartmentalization and Is Required for Normal Innervation of Outer Hair Cells. Front Cell Neurosci 12:211
Zheng, Jianbin; Chen, Long; Skinner, Owen S et al. (2018) ?-Glucocerebrosidase Modulators Promote Dimerization of ?-Glucocerebrosidase and Reveal an Allosteric Binding Site. J Am Chem Soc 140:5914-5924
Kenney, Grace E; Dassama, Laura M K; Pandelia, Maria-Eirini et al. (2018) The biosynthesis of methanobactin. Science 359:1411-1416
Joyce, Brian T; Zheng, Yinan; Zhang, Zhou et al. (2018) miRNA-Processing Gene Methylation and Cancer Risk. Cancer Epidemiol Biomarkers Prev 27:550-557
Chu, Lan H; Indramohan, Mohanalaxmi; Ratsimandresy, Rojo A et al. (2018) The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. Nat Commun 9:996
Symes, Yael R; Barrington, Clare; Austin, Jane et al. (2018) Advice to patients undergoing stem cell transplant: Content analysis of survivor peer support narratives. J Health Psychol 23:818-828
Lewis, Phillip L; Green, Richard M; Shah, Ramille N (2018) 3D-printed gelatin scaffolds of differing pore geometry modulate hepatocyte function and gene expression. Acta Biomater 69:63-70
Ugolkov, Andrey V; Bondarenko, Gennadiy I; Dubrovskyi, Oleksii et al. (2018) 9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma. Anticancer Drugs 29:717-724

Showing the most recent 10 out of 1972 publications