The central theme of the Developmental Biology (DB) Program is that cancer is often the result of corrupted developmental regulatory networks. We strive to use the powerful molecular genetics available in model organisms to understand fundamental signaling processes underlying normal development, and the abnormalities in these pathways that can lead to cancer. The goal is to provide key new targets for chemopreventive and chemotherapeutic interventions. Program Membership: Since the last renewal, the Developmental Biology Program has undergone several leadership changes. Dr. Bryant stepped down as the program leader to focus on rejuvenating the Graduate Program in Molecular Biology Genetics and Biochemistry and was replaced by Dr. Blumberg. After his stint as Graduate director ended, Dr. Bryant rejoined the program as Co-Leader in 2006 and was replaced by Dr. Marsh in 2007. Drs. Bode and Fallon retired and Dr. Brachmann transitioned to Associate Member. New Members include Dr. Maike Sander who moved from GF, and Drs. Peter Donovan, Taosheng Huang, Tom Schilling, and Rahul Warrior who joined the Program. The DB Program has 16 Members, representing five Departments and two Schools, and has $5,019,083 in direct cancer-related peer-reviewed funding, 1 project of which is funded by NCI for a direct total of $152,000. In 2007, Members published a total of 28 publications with 18 of those being cancer-related of which 22% were inter- and 6% were intra-related.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA062203-16
Application #
8215281
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2011-02-01
Budget End
2012-01-31
Support Year
16
Fiscal Year
2011
Total Cost
$12,546
Indirect Cost
Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Charney, Rebekah M; Forouzmand, Elmira; Cho, Jin Sun et al. (2017) Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program. Dev Cell 40:595-607.e4
HD iPSC Consortium (2017) Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice. Nat Neurosci 20:648-660
McCracken, A N; McMonigle, R J; Tessier, J et al. (2017) Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation. Leukemia 31:669-677
Barton, James C; Chen, Wen-Pin; Emond, Mary J et al. (2017) GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes. Blood Cells Mol Dis 63:15-20
Yan, Huaming; Romero-Lopez, Monica; Frieboes, Hermann B et al. (2017) Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression Without Increasing Invasiveness. IEEE Trans Biomed Eng 64:538-548
Klempner, Samuel J; Mehta, Pareen; Schrock, Alexa B et al. (2017) Cis-oriented solvent-front EGFR G796S mutation in tissue and ctDNA in a patient progressing on osimertinib: a case report and review of the literature. Lung Cancer (Auckl) 8:241-247
Molino, Nicholas M; Neek, Medea; Tucker, Jo Anne et al. (2017) Display of DNA on Nanoparticles for Targeting Antigen Presenting Cells. ACS Biomater Sci Eng 3:496-501
Lomeli, Naomi; Di, Kaijun; Czerniawski, Jennifer et al. (2017) Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats. Free Radic Biol Med 102:274-286
Huang, Jason Y; Samarasena, Jason B; Tsujino, Takeshi et al. (2017) EUS-guided portal pressure gradient measurement with a simple novel device: a human pilot study. Gastrointest Endosc 85:996-1001
Elbir, Haitham; Sitlani, Parth; Bergström, Sven et al. (2017) Chromosome and Megaplasmid Sequences of Borrelia anserina (Sakharoff 1891), the Agent of Avian Spirochetosis and Type Species of the Genus. Genome Announc 5:

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