The primary goal of the Biostatistics Core is to provide consulting services in support of cancer research. The primary activities of the Biostatistics Shared Resource include: 1) statistical and design issues for new studies;2) statistical analysis of data and consultation;and 3) development of clinical research protocols. The BSR has been involved in data analyses in a wide variety of projects, including genetic epidemiology studies;cancer etiology research;clinical studies to evaluate biblogical markers, assessment of diagnostic methods and treatment modalities, cancer prevention clinical trials, and in vitro studies. Specific services include the following: experimental design, definition of major and secondary endpoints, determination of sample size, development of randomization schemes, database design, database management and quality control, monitoring of side effects and compliance, determination of appropriate statistical tests, consideration of the assumptions underlying statistical procedures, performance of interim and final . analyses, interpretation of statistical results, and preparation of reports, abstracts, manuscripts, grant proposals. Current funding for the Biostatistics Core includes 1.3 FTE provided by the Cancer Center Support Grant. This provides partial support for four persons, Dr McLaren, Dr. Osann, Dr. Taylor, and Ms. Wen-Pin Chen. With institutional support, Ms. Yuhong Huang has joined our group as staff statistician, replacing Mr. Kuo-Tung Li. Additionally, Dr. Daniel L. Gillen, faculty member in the Department of Statistics, provides expertise regarding survival analysis, sequential testing, and interim analyses for clinical trials. These changes have increased our capability to provide service to Cancer Center Members and enable us to continue the tradition in which biostatistical consultation occurs early in protocol development and continues through frequent formal and informal discussions between the investigator and members of the Biostatistics Core. To further expand our capability, we request funds to support Dr. Argyrios Ziogas, Associate Professor, expert in statistical models for analysis of genetic data.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA062203-16
Application #
8215295
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2011-02-01
Budget End
2012-01-31
Support Year
16
Fiscal Year
2011
Total Cost
$135,931
Indirect Cost
Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Charney, Rebekah M; Forouzmand, Elmira; Cho, Jin Sun et al. (2017) Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program. Dev Cell 40:595-607.e4
HD iPSC Consortium (2017) Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice. Nat Neurosci 20:648-660
McCracken, A N; McMonigle, R J; Tessier, J et al. (2017) Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation. Leukemia 31:669-677
Barton, James C; Chen, Wen-Pin; Emond, Mary J et al. (2017) GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes. Blood Cells Mol Dis 63:15-20
Yan, Huaming; Romero-Lopez, Monica; Frieboes, Hermann B et al. (2017) Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression Without Increasing Invasiveness. IEEE Trans Biomed Eng 64:538-548
Klempner, Samuel J; Mehta, Pareen; Schrock, Alexa B et al. (2017) Cis-oriented solvent-front EGFR G796S mutation in tissue and ctDNA in a patient progressing on osimertinib: a case report and review of the literature. Lung Cancer (Auckl) 8:241-247
Molino, Nicholas M; Neek, Medea; Tucker, Jo Anne et al. (2017) Display of DNA on Nanoparticles for Targeting Antigen Presenting Cells. ACS Biomater Sci Eng 3:496-501
Lomeli, Naomi; Di, Kaijun; Czerniawski, Jennifer et al. (2017) Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats. Free Radic Biol Med 102:274-286
Huang, Jason Y; Samarasena, Jason B; Tsujino, Takeshi et al. (2017) EUS-guided portal pressure gradient measurement with a simple novel device: a human pilot study. Gastrointest Endosc 85:996-1001
Elbir, Haitham; Sitlani, Parth; Bergström, Sven et al. (2017) Chromosome and Megaplasmid Sequences of Borrelia anserina (Sakharoff 1891), the Agent of Avian Spirochetosis and Type Species of the Genus. Genome Announc 5:

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