The Growth Factors &Signaling (GF) program is comprised of Members who focus on the central theme of signal transduction pathways relevant to cancer initiation, progression and metastasis. There are three goals that characterize this group: 1) study signaling pathways relevant to these three phases of oncogenesis, 2) develop new tools for the study of these signaling pathways, 3) develop compounds and strategies to target key components of these pathways, and 4) translate basic information into clinical applications. The GF Program has 29 Members, representing 12 Departments and five Schools, and has $5,602,675 in direct cancer-related peer-reviewed funding, 8 projects of which are funded by NCI for a direct total of $1,177,989. In 2007, Members published a total of 76 publications with 46 of those being cancer-related of which 28% were inter- and 9% were intra-related. This breadth is evident in three areas of study: Immune System and Cancer, Signaling in Epithelial Cancers, and Tools for Cancer Research and Therapeutics. Membership and GF activities have been reorganized over the past funding period. Program leadership changed to Dr. Marian L. Waterman and Dr. Nancy Allbritton in 2003, with a second change in leadership in 2007 when Dr. Christopher Hughes replaced Dr. Allbritton after her departure from UC Irvine. Membership has significantly changed since the last funding period with an active recruitment of Members from the bioengineering and chemistry disciplines and other Members moving to the Developmental Biology (DB) Program.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of California Irvine
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Cox-Muranami, Wesley A; Nelson, Edward L; Li, G P et al. (2016) Large area magnetic micropallet arrays for cell colony sorting. Lab Chip 16:172-81
Klempner, Samuel J; Gershenhorn, Bruce; Tran, Phu et al. (2016) BRAFV600E Mutations in High-Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF-MEK Combination Therapy. Cancer Discov 6:594-600
Li, N; Pasricha, S; Bulsiewicz, W J et al. (2016) Effects of preceding endoscopic mucosal resection on the efficacy and safety of radiofrequency ablation for treatment of Barrett's esophagus: results from the United States Radiofrequency Ablation Registry. Dis Esophagus 29:537-43
Nolen, Shantell C; Lee, Brian; Shantharam, Shruti et al. (2016) The effects of sequential treatments on hippocampal volumes in malignant glioma patients. J Neurooncol 129:433-41
Bota, Daniela A; Davies, Kelvin J A (2016) Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders. Free Radic Biol Med 100:188-198
Pedram, Ali; Razandi, Mahnaz; Blumberg, Bruce et al. (2016) Membrane and nuclear estrogen receptor α collaborate to suppress adipogenesis but not triglyceride content. FASEB J 30:230-40
Greene, Christina L; Worrell, Stephanie G; Attwood, Stephen E et al. (2016) Emerging Concepts for the Endoscopic Management of Superficial Esophageal Adenocarcinoma. J Gastrointest Surg 20:851-60
Iyer, Neel S; Osann, Kathryn; Hsieh, Susie et al. (2016) Health Behaviors in Cervical Cancer Survivors and Associations with Quality of Life. Clin Ther 38:467-75
Leproux, Anaïs; Kim, You Me; Min, Jun Won et al. (2016) Differential diagnosis of breast masses in South Korean premenopausal women using diffuse optical spectroscopic imaging. J Biomed Opt 21:74001
McLaren, Christine E; Barton, James C; Subramaniam, V Nathan et al. (2016) Reply. Hepatology 63:2058-60

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