The University of California, Irvine Comprehensive Cancer Center is the only NCI-designated Comprehensive Cancer Center in Orange County and is a matrix-type organization. The Cancer Center serves approximately three million people in Orange County. The research goals of the Cancer Center are: 1) To contribute to the understanding of basic mechanisms that underlie the phenotype and genotype of cancer;2) To facilitate the translation of laboratory and epidemiologic research into hypothesis-driven clinical prevention and treatment studies;3) To conduct clinical prevention trials, whenever possible emanating from research generated in the Center;4) To define cancer risk in the diverse socioeconomic and multicultural society served by the Center and to develop research strategies to facilitate the prevention and early detection of cancer in these populations;and 5) To utilize the extensive education and training opportunities available at all levels as a major translational vehicle and to encourage activities that promote interdisciplinary, multidisciplinary, and transdisciplinary research. The Center is organized into four major Divisions: Basic Sciences, Clinical Research, Cancer Control &Population Sciences, and Education &Training. The Divisions interact through seven research programs: Carcinogenesis, Developmental Biology, Growth Factors &Signaling, Onco-lmaging &Spectroscopy, Population Sciences, Structural Molecular Biology, and Translational Oncology. The Center provides centralized support for Program functions through ten Shared Resource Facilities: Biobehavioral, Biostatistics, Clinical Research Office, DMA Sequencing, DMA &Protein MicroArray, Experimental Tissue, In-Vivo Functional Onco-lmaging, Optical Biology, Protein Mass Spectrometry, and Transgenic Mouse. The Education &Training Division facilitates integration of students into basic, clinical, and cancer control research activities in the various programs and accordingly enhances the translational capabilities of the Center. The 143 full Members of the Center are currently supported by $11,909,249 in direct NCI funds. Of the overall direct total of cancer-related funding ($36,214,529), $30,665,383 is peer-reviewed and $5,549,146 is non-peer-reviewed. Cancer Center Members entered 202 participants on prevention, therapeutic, and supportive care trials in the 2006-07 reporting year.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA062203-18S1
Application #
8709478
Study Section
Subcommittee G - Education (NCI)
Program Officer
Marino, Michael A
Project Start
1997-09-11
Project End
2014-01-31
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
18
Fiscal Year
2013
Total Cost
$25,000
Indirect Cost
$8,766
Name
University of California Irvine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Cox-Muranami, Wesley A; Nelson, Edward L; Li, G P et al. (2016) Large area magnetic micropallet arrays for cell colony sorting. Lab Chip 16:172-81
Klempner, Samuel J; Gershenhorn, Bruce; Tran, Phu et al. (2016) BRAFV600E Mutations in High-Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF-MEK Combination Therapy. Cancer Discov 6:594-600
Li, N; Pasricha, S; Bulsiewicz, W J et al. (2016) Effects of preceding endoscopic mucosal resection on the efficacy and safety of radiofrequency ablation for treatment of Barrett's esophagus: results from the United States Radiofrequency Ablation Registry. Dis Esophagus 29:537-43
Nolen, Shantell C; Lee, Brian; Shantharam, Shruti et al. (2016) The effects of sequential treatments on hippocampal volumes in malignant glioma patients. J Neurooncol 129:433-41
Bota, Daniela A; Davies, Kelvin J A (2016) Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders. Free Radic Biol Med 100:188-198
Pedram, Ali; Razandi, Mahnaz; Blumberg, Bruce et al. (2016) Membrane and nuclear estrogen receptor α collaborate to suppress adipogenesis but not triglyceride content. FASEB J 30:230-40
Greene, Christina L; Worrell, Stephanie G; Attwood, Stephen E et al. (2016) Emerging Concepts for the Endoscopic Management of Superficial Esophageal Adenocarcinoma. J Gastrointest Surg 20:851-60
Iyer, Neel S; Osann, Kathryn; Hsieh, Susie et al. (2016) Health Behaviors in Cervical Cancer Survivors and Associations with Quality of Life. Clin Ther 38:467-75
Leproux, Anaïs; Kim, You Me; Min, Jun Won et al. (2016) Differential diagnosis of breast masses in South Korean premenopausal women using diffuse optical spectroscopic imaging. J Biomed Opt 21:74001
McLaren, Christine E; Barton, James C; Subramaniam, V Nathan et al. (2016) Reply. Hepatology 63:2058-60

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