- In Vivo Functional Onco-Imaging (IVFOI) The aim of the In-Vivo Functional Onco-Imaging (IVFOI) Shared Resource is to enhance and support basic and clinical cancer researchers by providing them with the necessary expertise, imaging instrumentation, and image analysis techniques. The current available systems include three MRI scanners (3T- human, 4T- human and animal, and 7T- animal) and several cutting-edge multi-modality imaging systems for small animal imaging: a) combined MRI- Diffuse Optical Tomography (DOT) system, b) combined MRI-SPECT (Single Photon Emission Computed Tomography) system, and c) hybrid X-ray microCT-Optical Tomography system. The 4T MRI scanner provides an open architecture for development of new imaging methods, as well as for integration of a second modality such as DOT to form a combined system. Besides optical imaging, we have built world's first MR compatible SPECT system for small animal imaging. In addition to this we have developed a 3-D fluorescence & bioluminescence tomography system integrated with a micro CT. These multi- modality imaging systems are available for general use at this point. Beyond this small animal imaging instrumentation, we have been working on several new multi-modality systems for breast cancer imaging, MR- Optical and MR-Nuclear Imaging, and we are planning to make them available for Cancer Canter members in the next years. These systems will support various needs of CFCCC members in designing innovative imaging components into their studies, providing complementary anatomical and functional information. Additionally, our shared resource also supports translational clinical studies, with a precise protocol execution and a high standard quality control. For example, we have been supporting the collection of more than 900 breast MRI studies with unified protocols, and as such a large database has been collected. In the next cycle we will continue to support such clinical studies, and also to support translational clinical research using the multi- modality imaging systems in our portfolio, such as to evaluate the diagnostic performance of the combined MRI-Optical and MR-Nuclear imaging systems for breast cancer. Overall, the IVFOI Shared Resource provides CFCCC Members with ready access to state-of-the-art technologies, consultation for design of experiments and imaging protocols, and image acquisition and data analysis, as well as coordination among individual projects. Through the sharing of imaging and analysis protocols, we can integrate various information obtained from different projects to facilitate future collaborations between CFCCC members and to bring together basic scientists and clinical researchers to design and conduct clinical translational studies.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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University of California Irvine
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Yu, James; Landberg, Jenny; Shavarebi, Farbod et al. (2018) Bioengineering triacetic acid lactone production in Yarrowia lipolytica for pogostone synthesis. Biotechnol Bioeng 115:2383-2388
Oliver, Andrew; Kay, Matthew; Cooper, Kerry K (2018) Comparative genomics of cocci-shaped Sporosarcina strains with diverse spatial isolation. BMC Genomics 19:310
Mahlbacher, Grace; Curtis, Louis T; Lowengrub, John et al. (2018) Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment. J Immunother Cancer 6:10
Neek, Medea; Tucker, Jo Anne; Kim, Tae Il et al. (2018) Co-delivery of human cancer-testis antigens with adjuvant in protein nanoparticles induces higher cell-mediated immune responses. Biomaterials 156:194-203
McLelland, Bryce T; Lin, Bin; Mathur, Anuradha et al. (2018) Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats. Invest Ophthalmol Vis Sci 59:2586-2603
Bota, Daniela A; Chung, Jinah; Dandekar, Manisha et al. (2018) Phase II study of ERC1671 plus bevacizumab versus bevacizumab plus placebo in recurrent glioblastoma: interim results and correlations with CD4+ T-lymphocyte counts. CNS Oncol 7:CNS22
Han, Han; Qi, Ruxi; Zhou, Jeff Jiajing et al. (2018) Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction. Mol Cell 72:328-340.e8
Solares, Edwin A; Chakraborty, Mahul; Miller, Danny E et al. (2018) Rapid Low-Cost Assembly of the Drosophila melanogaster Reference Genome Using Low-Coverage, Long-Read Sequencing. G3 (Bethesda) 8:3143-3154
Wang, Yajun; Ngor, Arlene K; Nikoomanzar, Ali et al. (2018) Evolution of a General RNA-Cleaving FANA Enzyme. Nat Commun 9:5067
Qiu, Xiaolong; Lombardo, Jeremy A; Westerhof, Trisha M et al. (2018) Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells. Lab Chip 18:2776-2786

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