- Chemical & Structural Biology (CSB) The Chemical and Structural Biology (CSB) Program of the Chao Family Comprehensive Cancer Center (CFCCC) seeks to bring UC Irvine's considerable strengths in synthetic chemistry, structural biology, analytical chemistry and related areas to bear on anti-cancer research. These science areas tend to be pursued as single laboratory efforts. Thus, a major thrust of the CSB program is building collaborations and bridges between CSB researchers and cancer biologists and clinicians. In addition to the traditional methods of developing collaborations (e.g., topical retreats and symposia), the CSB leadership runs a very successful molecular matchmaking service, bringing together synthetic chemists, structural biologists and biologists with interesting small molecules. Notable successes of the matchmaking service include a new class of anti-nutrient transporter compounds with exciting anti-cancer activities in vitro and in animal models. Through its activities, the CFCCC directly contributes to the success of the anti-cancer research pursued by CSB members. For example, neuronal nitric oxide synthase emerged as a target for melanoma, and connections forged by the CFCCC led quickly to experiments with highly specific nNOS inhibitors. Similarly, success in the area of analytical chemistry connecting biological recognition with electronics led to connections with prostate and bladder cancer physicians to guide experiments leading to a clinical trial. The CFCCC also provides pilot project funding, which help initiate studies between a synthetic chemist and biologist leading to new types of anti-breast cancer compounds. The CSB leadership also helps to expand the research of its members into cancer-related areas; for example, researchers with a promising new experimental technique for mapping protein-protein interactions with proteomics MS were introduced to different potential collaborators opening new doors and avenues of research. Thus, the CSB program leverages existing efforts and strengths to amplify the quantity and quality of anti-cancer research taking place at UC Irvine. Membership: 22 Members from 8 Departments Funding: $459,979 NCI (Totals); $4,141,394 Other Peer-Reviewed (Totals) Publications: 158 Publications, 16% Inter-programmatic; 6% Intra-programmatic

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA062203-21
Application #
9416958
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-02-01
Budget End
2019-01-31
Support Year
21
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92617
Yu, James; Landberg, Jenny; Shavarebi, Farbod et al. (2018) Bioengineering triacetic acid lactone production in Yarrowia lipolytica for pogostone synthesis. Biotechnol Bioeng 115:2383-2388
Oliver, Andrew; Kay, Matthew; Cooper, Kerry K (2018) Comparative genomics of cocci-shaped Sporosarcina strains with diverse spatial isolation. BMC Genomics 19:310
Mahlbacher, Grace; Curtis, Louis T; Lowengrub, John et al. (2018) Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment. J Immunother Cancer 6:10
Neek, Medea; Tucker, Jo Anne; Kim, Tae Il et al. (2018) Co-delivery of human cancer-testis antigens with adjuvant in protein nanoparticles induces higher cell-mediated immune responses. Biomaterials 156:194-203
McLelland, Bryce T; Lin, Bin; Mathur, Anuradha et al. (2018) Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats. Invest Ophthalmol Vis Sci 59:2586-2603
Bota, Daniela A; Chung, Jinah; Dandekar, Manisha et al. (2018) Phase II study of ERC1671 plus bevacizumab versus bevacizumab plus placebo in recurrent glioblastoma: interim results and correlations with CD4+ T-lymphocyte counts. CNS Oncol 7:CNS22
Han, Han; Qi, Ruxi; Zhou, Jeff Jiajing et al. (2018) Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction. Mol Cell 72:328-340.e8
Solares, Edwin A; Chakraborty, Mahul; Miller, Danny E et al. (2018) Rapid Low-Cost Assembly of the Drosophila melanogaster Reference Genome Using Low-Coverage, Long-Read Sequencing. G3 (Bethesda) 8:3143-3154
Wang, Yajun; Ngor, Arlene K; Nikoomanzar, Ali et al. (2018) Evolution of a General RNA-Cleaving FANA Enzyme. Nat Commun 9:5067
Qiu, Xiaolong; Lombardo, Jeremy A; Westerhof, Trisha M et al. (2018) Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells. Lab Chip 18:2776-2786

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