- Onco-Imaging and Biotechnology (OIB) The broad goal of the OIB Program is to develop and assess quantitative systems and technologies that improve detection, clinical management, and quality of life for cancer patients. OIB is strongly interdisciplinary, integrating basic scientists with technologists and clinicians and is focused around 3 key themes. Critically, each of the themes includes basic science, technology development, and translational research activities spanning from animal models to human subjects in various types of cancers, including breast, skin, GI, oral cavity, prostate, and brain. We also apply emerging technologies in multi-center and cooperative group clinical trials in order to standardize and validate methods and endpoints for improved cancer detection and clinical management. The three themes are: 1) Cancer imaging and treatment using Biophotonics and Biomedical Optics technologies, including a broad range of non-linear optical microscopies, Laser Microbeams, Optical Coherence Tomography, Acousto-Optic Imaging and Elastography, Laser Speckle Imaging, Spatial Frequency Domain Imaging, and Diffuse Optical Spectroscopy and Imaging; 2) Cancer imaging and treatment using MRI, Nuclear, X-Ray/CT, multi-Modality technologies; and 3) Cancer detection and therapy using molecular, cellular, and material technologies, from nano- and microfluidic platforms and integrated ?lab-on-a-chip? and ?body-on- a-chip? systems, to advanced cellular and molecular diagnostics for improved cancer detection and therapy. Importantly, the new technologies and methods for engineering cellular systems we are developing are optimized such that their integration into multi-system platforms allows visualization using many of the technologies developed in themes 1 and 2. OIB leadership works to leverage these technologies to improve cancer detection, clinical management and patient quality of life through three Specific Aims: 1) Develop novel tools for cancer detection and treatment; 2) Foster multi-disciplinary collaborations to validate these tools in preclinical cancer models; and, 3) Validate novel technologies in multi-center and cooperative group clinical trials. Membership: 28 Members from 15 Departments Funding: $3,516,292 NCI (Totals); $5,218,874 Other Peer-Reviewed (Totals) Publications: 347 Publications, 11% Inter-programmatic; 22% Intra-programmatic

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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University of California Irvine
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Charney, Rebekah M; Forouzmand, Elmira; Cho, Jin Sun et al. (2017) Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program. Dev Cell 40:595-607.e4
HD iPSC Consortium (2017) Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice. Nat Neurosci 20:648-660
McCracken, A N; McMonigle, R J; Tessier, J et al. (2017) Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation. Leukemia 31:669-677
Barton, James C; Chen, Wen-Pin; Emond, Mary J et al. (2017) GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes. Blood Cells Mol Dis 63:15-20
Yan, Huaming; Romero-Lopez, Monica; Frieboes, Hermann B et al. (2017) Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression Without Increasing Invasiveness. IEEE Trans Biomed Eng 64:538-548
Klempner, Samuel J; Mehta, Pareen; Schrock, Alexa B et al. (2017) Cis-oriented solvent-front EGFR G796S mutation in tissue and ctDNA in a patient progressing on osimertinib: a case report and review of the literature. Lung Cancer (Auckl) 8:241-247
Molino, Nicholas M; Neek, Medea; Tucker, Jo Anne et al. (2017) Display of DNA on Nanoparticles for Targeting Antigen Presenting Cells. ACS Biomater Sci Eng 3:496-501
Lomeli, Naomi; Di, Kaijun; Czerniawski, Jennifer et al. (2017) Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats. Free Radic Biol Med 102:274-286
Huang, Jason Y; Samarasena, Jason B; Tsujino, Takeshi et al. (2017) EUS-guided portal pressure gradient measurement with a simple novel device: a human pilot study. Gastrointest Endosc 85:996-1001
Elbir, Haitham; Sitlani, Parth; Bergström, Sven et al. (2017) Chromosome and Megaplasmid Sequences of Borrelia anserina (Sakharoff 1891), the Agent of Avian Spirochetosis and Type Species of the Genus. Genome Announc 5:

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