The mission of the Vanderbilt-lngram Cancer Center Informatics Shared Resource (ISR) is to catalyze the research productivity of VICC investigators by providing two essential ingredients for success. The first is a flexible physical and electronic infrastructure for acquiring, storing, communicating and analyzing data arising from wet bench, translational, and clinical cancer research. The second is assistance by senior-level staff and faculty in the interpretation of research datasets using state-of-the-art analysis methods where they are available, and the development of novel bioinformatics methods where current analytical approaches are insufficient. The ISR in its current form has evolved from the Tissue Clinical Informatics Shared Resource that was created during the preceding grant period. That resource had a focus on the informatics of characterization, annotation and tracking of tissue samples associated with clinical trials and basic research. At the time of the last competitive renewal, this shared resource received an 'Outstanding' rating. We have broadened the scope of the resource to support all of the basic, translational and clinical research of VICC, thus leading to our renaming ofthe resource in the current application. The resource has been strengthened by two new faculty hires - Mia Levy, M.D., and Zhongming Zhao, Ph.D. Dr. Levy is a Stanford-trained medical oncologist with a Master's degree in Biomedical Informatics who serves as the VICC Clinical Informatics faculty lead for development and deployment of advanced clinical research and cancer care systems. Dr. Zhao is Chief Bioinformatics Officer for VICC and heads a new Bioinformatics Data Interpretation service available to Center Investigators. Dan Masys, M.D., a medical oncologist and chair of Vanderbilt's Department of Biomedical Informatics, leads the resource, and Scott Sobecki, an experienced senior information technology professional, directs a team of in-house programmers and systems support staff. The ISR benefits from the information technology resources of Vanderbilt University Medical Center, which provide a fertile environment for informatics innovations in support of basic, translational and clinical cancer research, and cancer care that will measurably advance the state of the art.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA068485-16
Application #
8379929
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
16
Fiscal Year
2012
Total Cost
$114,488
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Takata, Yumie; Xiang, Yong-Bing; Burk, Raymond F et al. (2018) Plasma selenoprotein P concentration and lung cancer risk: results from a case-control study nested within the Shanghai Men's Health Study. Carcinogenesis 39:1352-1358
Feng, Yinnian; Reinherz, Ellis L; Lang, Matthew J (2018) ?? T Cell Receptor Mechanosensing Forces out Serial Engagement. Trends Immunol 39:596-609
Sucre, Jennifer M S; Deutsch, Gail H; Jetter, Christopher S et al. (2018) A Shared Pattern of ?-Catenin Activation in Bronchopulmonary Dysplasia and Idiopathic Pulmonary Fibrosis. Am J Pathol 188:853-862
Rogers, Meredith C; Lamens, Kristina D; Shafagati, Nazly et al. (2018) CD4+ Regulatory T Cells Exert Differential Functions during Early and Late Stages of the Immune Response to Respiratory Viruses. J Immunol 201:1253-1266
Rosenberg, Adam J; Nickels, Michael L; Schulte, Michael L et al. (2018) Automated radiosynthesis of 5-[11C]l-glutamine, an important tracer for glutamine utilization. Nucl Med Biol 67:10-14
Dean, Donnatesa A L; Griffith, Derek M; McKissic, Sydika A et al. (2018) Men on the Move-Nashville: Feasibility and Acceptability of a Technology-Enhanced Physical Activity Pilot Intervention for Overweight and Obese Middle and Older Age African American Men. Am J Mens Health 12:798-811
Choi, Eunyoung; Lantz, Tyler L; Vlacich, Gregory et al. (2018) Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach. Gut 67:1595-1605
Parl, Fritz F; Crooke, Philip S; Plummer Jr, W Dale et al. (2018) Genomic-Epidemiologic Evidence That Estrogens Promote Breast Cancer Development. Cancer Epidemiol Biomarkers Prev 27:899-907
Marks, Christian R; Shonesy, Brian C; Wang, Xiaohan et al. (2018) Activated CaMKII? Binds to the mGlu5 Metabotropic Glutamate Receptor and Modulates Calcium Mobilization. Mol Pharmacol 94:1352-1362
Singh, Kshipra; Coburn, Lori A; Asim, Mohammad et al. (2018) Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Cancer Res 78:4303-4315

Showing the most recent 10 out of 2462 publications