was initially included for the support and application of imaging of animal models of cancer. The resource is provided by the Vanderbilt University Institute of Imaging Science (VUIIS), a trans-institutional program established in 2002 that brings together a diverse and expert group of imaging scientists dedicated to the development and application of advanced imaging techniques in biomedical research. Over the past five years, the Cancer Center has been the major user of animal imaging, and cancer applications dominate usage of the imaging facilities. For example, in the past year, over 25 different principal investigators from the Vanderbilt-lngram Cancer Center (VICC) have used the resource, engaging the staff and equipment on more than 50 different projects/studies. In total, these studies used 4,650 hours of high-field MRI and MRS, nuclear imaging (PET, SPECT, and CT), optical imaging, and ultrasound. Today the resource is a very active component of the CCSG. This renewal seeks support for a major expansion to include human research imaging. In particular, we will provide organizational, administrative and financial support to encourage stronger and more formal collaborations between radiologists, imaging scientists and clinical oncologists working as teams engaged in the evaluation of clinical trials. We will also work with VICC investigators to identify appropriate imaging biomarkers and implement quantitative imaging methods that can be used as surrogate measures for clinical outcomes and that may be incorporated into clinical trials of novel anticancer agents. Thus, the aims of the Imaging Resource are to enable VICC investigators to: 1. Execute quantitative in vivo imaging studies in models of cancer, 2. Apply and validate MRI, optical, CT, PET, SPECT, and ultrasound methods for the noninvasive detection and characterization of treatment response in small animals; 3. Incorporate emerging, and clinically relevant, quantitative MRI and PET protocols into appropriate Phase I, II, and 111 clinical trials established at VICC. A fundamental strength of this shared resource is that the imaging science expertise obtained in preclinical studies with leading cancer scientists and physicians can be directly translated into, and inform, clinical practice.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
United States
Zip Code
Paul, Pritha; Rellinger, Eric J; Qiao, Jingbo et al. (2017) Elevated TIMP-1 expression is associated with a prometastatic phenotype, disease relapse, and poor survival in neuroblastoma. Oncotarget 8:82609-82620
Stephenson, Jason R; Wang, Xiaohan; Perfitt, Tyler L et al. (2017) A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. J Neurosci 37:2216-2233
Bouziat, Romain; Hinterleitner, Reinhard; Brown, Judy J et al. (2017) Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science 356:44-50
Moyo, T K; Wilson, C S; Moore, D J et al. (2017) Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition. Oncogene 36:4653-4661
Vilgelm, Anna E; Cobb, Priscilla; Malikayil, Kiran et al. (2017) MDM2 Antagonists Counteract Drug-Induced DNA Damage. EBioMedicine 24:43-55
LePage, Daniel P; Metcalf, Jason A; Bordenstein, Sarah R et al. (2017) Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility. Nature 543:243-247
Li, Jun; Smith, Jarrod A; Dawson, Eric S et al. (2017) Optimized Translocator Protein Ligand for Optical Molecular Imaging and Screening. Bioconjug Chem 28:1016-1023
Zhang, Juliet; Weinrich, Jarret A P; Russ, Jeffrey B et al. (2017) A Role for Dystonia-Associated Genes in Spinal GABAergic Interneuron Circuitry. Cell Rep 21:666-678
Aune, T M; Crooke 3rd, P S; Patrick, A E et al. (2017) Expression of long non-coding RNAs in autoimmunity and linkage to enhancer function and autoimmune disease risk genetic variants. J Autoimmun 81:99-109
Esbenshade, Adam J; Zhao, Zhiguo; Aftandilian, Catherine et al. (2017) Multisite external validation of a risk prediction model for the diagnosis of blood stream infections in febrile pediatric oncology patients without severe neutropenia. Cancer 123:3781-3790

Showing the most recent 10 out of 2332 publications