The goal of the Human Tissue Acquisition and Pathology Shared Resource (HTAP) is to provide human tissue samples and histology services to support translafional and preclinical aspects of cancer research. This resource has been in operation since 1993;at the last competitive renewal, this shared resource received an "Outstanding" rating. HTAP provides researchers with access to a wide variety of human specimens and fissues. HTAP's objectives are to collect, process, bank, and distribute remnant human tissues (both normal and neoplastic) from routine surgical resections and autopsies for use by peer-reviewed and funded Vanderbilt-lngram Cancer Center (VICC) investigators in basic, clinical, and translafional research studies. This includes providing the highest quality, well-characterized fresh, frozen, and fixed tissues suitable for a wide range of molecular, biochemical, and tissue analyses. HTAP will also assist with the collection and banking of biopsy material for specific cancer-related clinical trials and other projects and will perform quality control to ensure that the relevant tissue is supplied to the researcher, and that fissues are suitable for the planned research (e.g., not necrofic or involved by unsuspected disease processes). HTAP is well situated in regards to space and equipment. Services highly utilized by VICC investigators and only provided by HTAP include laser capture microscopy, tissue array construction and image analysis. This shared resource is of critical importance for the translational work of VICC invesfigators. Mary Zutter, M.D., Professor of Pathology and Cancer Biology and Ingram Professor of Cancer Research, became scientific director in May 2009. Dr. Zutter directs a research laboratory that focuses on the role of cell adhesion molecules in host-tumor interactions. She has been funded continuously by the NIH for the past 17 years and is currently supported by three R01 grants from the NCI. In addition, she is board certified in Anatomic and Clinical Pathology and directs the Division of Hematopathology. She is assisted by a staff with decades of experience and by the Informafics Shared Resource, under the direction of Dan Masys, M.D.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Vanderbilt University Medical Center
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Han, Ying; Signorello, Lisa B; Strom, Sara S et al. (2015) Generalizability of established prostate cancer risk variants in men of African ancestry. Int J Cancer 136:1210-7
Sanders, Melinda E; Schuyler, Peggy A; Simpson, Jean F et al. (2015) Continued observation of the natural history of low-grade ductal carcinoma in situ reaffirms proclivity for local recurrence even after more than 30 years of follow-up. Mod Pathol 28:662-9
Chaturvedi, R; de Sablet, T; Asim, M et al. (2015) Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene 34:3429-40
Vilgelm, Anna E; Pawlikowski, Jeff S; Liu, Yan et al. (2015) Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells. Cancer Res 75:181-93
Wei, Jinxiong; Noto, Jennifer M; Zaika, Elena et al. (2015) Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner. Gut 64:1040-8
Carrillo, A M; Bouska, A; Arrate, M P et al. (2015) Mdmx promotes genomic instability independent of p53 and Mdm2. Oncogene 34:846-56
Balko, Justin M; Giltnane, Jennifer M; Wang, Kai et al. (2014) Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets. Cancer Discov 4:232-45
Weeke, Peter; Mosley, Jonathan D; Hanna, David et al. (2014) Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome. J Am Coll Cardiol 63:1430-7
Cheng, Feixiong; Jia, Peilin; Wang, Quan et al. (2014) Studying tumorigenesis through network evolution and somatic mutational perturbations in the cancer interactome. Mol Biol Evol 31:2156-69
Peng, Dun-Fa; Hu, Tian-Ling; Soutto, Mohammed et al. (2014) Loss of glutathione peroxidase 7 promotes TNF-?-induced NF-?B activation in Barrett's carcinogenesis. Carcinogenesis 35:1620-8

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