Although we have witnessed tremendous success in our cancer clinics in the past five years, over half of our patients will receive frontline treatments that are more than 25 years old. That sobering statistic indicates that we must continue to recruit the next generation of cancer scientists and continue to innovate in our labs and our shared resources. Developmental Funds provide essential support for the Vanderbilt-Ingram Cancer Center's (VICC) strategic initiatives. During the current project period, this support was applied towards recruitment of new faculty and for support of pilot projects. A total of eight new faculty members were provided with recruitment support; including a key strategic recruitment to underscore our commitment to smoking cessation. A total of 11 pilot projects were funded over the project period with a significant publication and a subsequent funding of next to 20-fold more than initially invested. $102,498 per year would be allocated for new faculty recruitment in targeted strategic areas, including but not limited to cancer genetics, genomics and epigenetics, cancer drug discovery, personalized cancer medicine, phase I investigations, cancer epidemiology and population-based research, cancer control and hematologic and neurologic malignancies. A request of $200,000 per year will support three types of pilot projects: 1) highly innovative projects focusing on proof-of- concept or translational research, 2) preliminary collaborative investigations leading to multi-investigator grants, and 3) projects that closely align to our strategic plan in order to enhance key initiatives. Developmental funds will also be used to support seven staff investigators in clinical, basic, population and disparities research. The VICC has a proven track record in the stewardship of these funds. The current request, in concert with the continued commitment of VICC discretionary funds, enables the Director to support activities critical to the sustained research excellence of the VICC.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA068485-23
Application #
9553501
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
23
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232
Takata, Yumie; Xiang, Yong-Bing; Burk, Raymond F et al. (2018) Plasma selenoprotein P concentration and lung cancer risk: results from a case-control study nested within the Shanghai Men's Health Study. Carcinogenesis 39:1352-1358
Feng, Yinnian; Reinherz, Ellis L; Lang, Matthew J (2018) ?? T Cell Receptor Mechanosensing Forces out Serial Engagement. Trends Immunol 39:596-609
Sucre, Jennifer M S; Deutsch, Gail H; Jetter, Christopher S et al. (2018) A Shared Pattern of ?-Catenin Activation in Bronchopulmonary Dysplasia and Idiopathic Pulmonary Fibrosis. Am J Pathol 188:853-862
Rogers, Meredith C; Lamens, Kristina D; Shafagati, Nazly et al. (2018) CD4+ Regulatory T Cells Exert Differential Functions during Early and Late Stages of the Immune Response to Respiratory Viruses. J Immunol 201:1253-1266
Rosenberg, Adam J; Nickels, Michael L; Schulte, Michael L et al. (2018) Automated radiosynthesis of 5-[11C]l-glutamine, an important tracer for glutamine utilization. Nucl Med Biol 67:10-14
Dean, Donnatesa A L; Griffith, Derek M; McKissic, Sydika A et al. (2018) Men on the Move-Nashville: Feasibility and Acceptability of a Technology-Enhanced Physical Activity Pilot Intervention for Overweight and Obese Middle and Older Age African American Men. Am J Mens Health 12:798-811
Choi, Eunyoung; Lantz, Tyler L; Vlacich, Gregory et al. (2018) Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach. Gut 67:1595-1605
Parl, Fritz F; Crooke, Philip S; Plummer Jr, W Dale et al. (2018) Genomic-Epidemiologic Evidence That Estrogens Promote Breast Cancer Development. Cancer Epidemiol Biomarkers Prev 27:899-907
Marks, Christian R; Shonesy, Brian C; Wang, Xiaohan et al. (2018) Activated CaMKII? Binds to the mGlu5 Metabotropic Glutamate Receptor and Modulates Calcium Mobilization. Mol Pharmacol 94:1352-1362
Singh, Kshipra; Coburn, Lori A; Asim, Mohammad et al. (2018) Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Cancer Res 78:4303-4315

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