The Bioanalytical/Pharmacokinetics Shared Resource (BPSR) is a shared resource that provides Knight members with access to state-of-the art liquid chromatography tandem mass spectrometry (LC-MS/MS) and gas chromatography mass spectrometry (GC-MS). The BPSR provides expert consultation on the design of analytical methods and pharmacokinetic studies and assistance with the analysis of PK data.
The Specific Aims of the facility are: 1) to provide Knight members access to instrumentation that is maintained for small molecule analysis and includes LC-MS/MS and GC-MS instruments;2) to provide Knight members with a full service laboratory to develop analytical methods, prepare samples and provide data analysis for both clinical and basic science investigations;3) to provide Knight members with assistance in the design and interpretation of pharmacokinetic studies for both animal models and Phase 1 investigations.

Public Health Relevance

The study of the absorption, distribution, metabolism and elimination of established and experimental drugs is essential to the Knight Cancer Institute's program of personalized medicine. The BPSR enables investigators to ask quantitative questions about small molecules in all phases of translational research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA069533-15S1
Application #
8530492
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
15
Fiscal Year
2012
Total Cost
$4,687
Indirect Cost
$1,136
Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Farrell, Amy S; Joly, Meghan Morrison; Allen-Petersen, Brittany L et al. (2017) MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nat Commun 8:1728
De Maria, Alicia; Wilmarth, Phillip A; David, Larry L et al. (2017) Proteomic Analysis of the Bovine and Human Ciliary Zonule. Invest Ophthalmol Vis Sci 58:573-585
Danelishvili, Lia; Chinison, Jessica J J; Pham, Tuan et al. (2017) The Voltage-Dependent Anion Channels (VDAC) of Mycobacterium avium phagosome are associated with bacterial survival and lipid export in macrophages. Sci Rep 7:7007
Avenarius, Matthew R; Krey, Jocelyn F; Dumont, Rachel A et al. (2017) Heterodimeric capping protein is required for stereocilia length and width regulation. J Cell Biol 216:3861-3881
Cassidy, Pamela B; Liu, Tong; Florell, Scott R et al. (2017) A Phase II Randomized Placebo-Controlled Trial of Oral N-acetylcysteine for Protection of Melanocytic Nevi against UV-Induced Oxidative Stress In Vivo. Cancer Prev Res (Phila) 10:36-44
Tsujikawa, Takahiro; Kumar, Sushil; Borkar, Rohan N et al. (2017) Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis. Cell Rep 19:203-217
Kwon, Sunjong; Chin, Koei; Nederlof, Michel et al. (2017) Quantitative, in situ analysis of mRNAs and proteins with subcellular resolution. Sci Rep 7:16459
Midgett, Madeline; López, Claudia S; David, Larry et al. (2017) Increased Hemodynamic Load in Early Embryonic Stages Alters Endocardial to Mesenchymal Transition. Front Physiol 8:56
Krey, J F; Wilmarth, P A; David, L L et al. (2017) Analysis of the Proteome of Hair-Cell Stereocilia by Mass Spectrometry. Methods Enzymol 585:329-354
Xu, Xiaowei; De Angelis, Carmine; Burke, Kathleen A et al. (2017) HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer. Clin Cancer Res 23:5123-5134

Showing the most recent 10 out of 248 publications