Critical to many labs within Cancer Center is the ability to examine tissues and cells at the subcellular level, to count, isolate and measure cells, and to utilize non-invasive techniques to monitor tumorigenesis in mouse models. However, individual labs can rarely afford the state-of-the-art instrumentation required for many of these studies. Based on this need, a microscope core was created in 2002 and administered through the former Laboratory Instrumentation Shared Resource (LISR). The LISR's imaging capabilities have considerably expanded over the years with the acquisition of several important pieces of equipment, including a Leica TCS SP5 laser scanning confocal microscope, a laser capture tissue microdissection instrument, a time-lapse microscope with WeatherStation, and a IVIS Lumina imaging system for live animal studies. As a result of this growth, the former LISR is now the Microscopy and Imaging Share Resource (MISR), which serves as a centralized facility for access to imaging instruments within the Cancer Center. One important function of the MISR is to offer technical support to users and to properly maintain the complex instrumentation housed in the facility through annual maintenance services as well as routine calibrations. Moreover, the facility is responsible for upgrades, repairs, and acquisition of new equipment according to the needs of the cancer center researchers. Non-imaging services previously provided by the LISR, such as freezer monitoring, darkroom maintenance, and repairs of shared centrifuges, are now administered and supported entirely through institutional funds.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA071789-13
Application #
8369396
Study Section
Subcommittee G - Education (NCI)
Project Start
2012-07-01
Project End
2017-06-30
Budget Start
2012-09-21
Budget End
2013-08-31
Support Year
13
Fiscal Year
2012
Total Cost
$21,678
Indirect Cost
$5,820
Name
University of Hawaii
Department
Type
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Citronberg, Jessica S; Wilkens, Lynne R; Le Marchand, Loic et al. (2018) Plasma lipopolysaccharide-binding protein and colorectal cancer risk: a nested case-control study in the Multiethnic Cohort. Cancer Causes Control 29:115-123
Panizza, Chloe E; Shvetsov, Yurii B; Harmon, Brook E et al. (2018) Testing the Predictive Validity of the Healthy Eating Index-2015 in the Multiethnic Cohort: Is the Score Associated with a Reduced Risk of All-Cause and Cause-Specific Mortality? Nutrients 10:
Marciel, Michael P; Khadka, Vedbar S; Deng, Youpeng et al. (2018) Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget 9:13407-13422
Park, S-Y; Wilkens, L R; Maskarinec, G et al. (2018) Weight change in older adults and mortality: the Multiethnic Cohort Study. Int J Obes (Lond) 42:205-212
Gong, J; Nishimura, K K; Fernandez-Rhodes, L et al. (2018) Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. Int J Obes (Lond) 42:384-390
Pokhrel, Pallav; Herzog, Thaddeus A; Fagan, Pebbles et al. (2018) E-cigarette Advertising Exposure, Explicit and Implicit Harm Perceptions, and E-Cigarette use Susceptibility Among Non-Smoking Young Adults. Nicotine Tob Res :
Wu, Eric M; Hernandez, Brenda Y; Wong, Linda L (2018) Hepatocellular carcinoma in Micronesians, a growing Pacific Islander population in the U.S. Open J Gastroenterol 8:
Murphy, Sharon E; von Weymarn, Linda B; Parenteau, Marc et al. (2018) Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N-glucuronide by African American Smokers. Chem Res Toxicol 31:168-175
Loo, Lenora W M; Williams, Makana; Hernandez, Brenda Y (2018) The high and heterogeneous burden of breast cancer in Hawaii: A unique multiethnic U.S. Population. Cancer Epidemiol 58:71-76
Hernandez, Brenda Y; Tareg, Aileen C; Reichhardt, Martina et al. (2018) Randomized controlled trial evaluating the utility of urine HPV DNA for cervical cancer screening in a Pacific Island population. J Glob Health Rep 2:

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