Critical to many labs within Cancer Center is the ability to examine tissues and cells at the subcellular level, to count, isolate and measure cells, and to utilize non-invasive techniques to monitor tumorigenesis in mouse models. However, individual labs can rarely afford the state-of-the-art instrumentation required for many of these studies. Based on this need, a microscope core was created in 2002 and administered through the former Laboratory Instrumentation Shared Resource (LISR). The LISR's imaging capabilities have considerably expanded over the years with the acquisition of several important pieces of equipment, including a Leica TCS SP5 laser scanning confocal microscope, a laser capture tissue microdissection instrument, a time-lapse microscope with WeatherStation, and a IVIS Lumina imaging system for live animal studies. As a result of this growth, the former LISR is now the Microscopy and Imaging Share Resource (MISR), which serves as a centralized facility for access to imaging instruments within the Cancer Center. One important function of the MISR is to offer technical support to users and to properly maintain the complex instrumentation housed in the facility through annual maintenance services as well as routine calibrations. Moreover, the facility is responsible for upgrades, repairs, and acquisition of new equipment according to the needs of the cancer center researchers. Non-imaging services previously provided by the LISR, such as freezer monitoring, darkroom maintenance, and repairs of shared centrifuges, are now administered and supported entirely through institutional funds.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA071789-14
Application #
8565942
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
14
Fiscal Year
2013
Total Cost
$20,084
Indirect Cost
$5,378
Name
University of Hawaii
Department
Type
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Shimizu, Yoshiko; Furuya, Hideki; Tamashiro, Paulette M et al. (2018) Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model. Carcinogenesis 39:47-55
Aumueller, Nicole; Boushey, Carol J; Franke, Adrian A et al. (2018) Diet quality measured by four a priori-defined diet quality indices is associated with lipid-soluble micronutrients in the Multiethnic Cohort Study (MEC). Eur J Clin Nutr :
Huang, Brian Z; Le Marchand, Loic; Haiman, Christopher A et al. (2018) Atopic allergic conditions and pancreatic cancer risk: Results from the Multiethnic Cohort Study. Int J Cancer 142:2019-2027
Jenkins, Mark A; Win, Aung Ko; Templeton, Allyson S et al. (2018) Cohort Profile: The Colon Cancer Family Registry Cohort (CCFRC). Int J Epidemiol 47:387-388i
Naderi, Ali (2018) SRARP and HSPB7 are epigenetically regulated gene pairs that function as tumor suppressors and predict clinical outcome in malignancies. Mol Oncol 12:724-755
Franke, Adrian A; Li, Xingnan; Menden, Ariane et al. (2018) Oxytocin analysis from human serum, urine, and saliva by orbitrap liquid chromatography-mass spectrometry. Drug Test Anal :
Fanidi, Anouar; Muller, David C; Yuan, Jian-Min et al. (2018) Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3). J Natl Cancer Inst 110:
Rohrmann, Sabine; Shvetsov, Yurii B; Morimoto, Yukiko et al. (2018) Self-reported dietary flavonoid intake and serum markers of inflammation: the multiethnic cohort. Cancer Causes Control 29:601-607
Faouzi, Malika; Neupane, Ram P; Yang, Jian et al. (2018) Areca nut extracts mobilize calcium and release pro-inflammatory cytokines from various immune cells. Sci Rep 8:1075
Nishioka, Scott T; Sato, Miles M; Wong, Linda L et al. (2018) Clinical and molecular sub-classification of hepatocellular carcinoma relative to alpha-fetoprotein level in an Asia-Pacific island cohort. Hepatoma Res 4:

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