The Pathology Shared Resource (PSR) was created approximately 7 years ago to provide histology and tissue procurement services to support basic, epidemiologic, translational, and clinical research studies conducted both within and outside of the University of Hawai'i Cancer Center (UHCC). Prior to the existence of the PSR, tissue based research at the UHCC was severely limited due to lack of a centralized histopathology service and tissue repository. Since its establishment, usage of the PSR has consistently increased and has facilitated multiple high quality research endeavors by UHCC members. Current services offered by the Resource include a full range of histology services, professional pathology consultation, as well as specialized laboratory services such as tissue microarray (TMA) construction and consultation for laser-capture microdissection (LCM). In addition to these functions, the PSR manages a large, clinically annotated archival tissue repository and facilitates investigator-initiated fresh tissue collection from area hospitals. Future directions for the PSR include establishment of a prospectively collected biorepository in partnership with Queens Medical Center (QMC), the largest cancer care provider in Hawai'i, as well as other consortium hospital members. As a newly emerging facility, the PSR was not supported by the CCSG during the prior funding period. Given that the PSR is now a mature enterprise whose endeavors are expected to continue to expand, we now request CCSG support. CCSG support will also be crucial to the future functioning of this resource, in view of the recent termination of SEER funding for the archival tissue repository in 2010.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Hawaii
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Park, Sungshim Lani; Kotapati, Srikanth; Wilkens, Lynne R et al. (2014) 1,3-Butadiene exposure and metabolism among Japanese American, Native Hawaiian, and White smokers. Cancer Epidemiol Biomarkers Prev 23:2240-9
Park, S Lani; Fesinmeyer, Megan D; Timofeeva, Maria et al. (2014) Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia. J Natl Cancer Inst 106:dju061
Harmon, Brook E; Little, Melissa A; Woekel, Erica D et al. (2014) Ethnic differences and predictors of colonoscopy, prostate-specific antigen, and mammography screening participation in the multiethnic cohort. Cancer Epidemiol 38:162-7
Hopenhayn, Claudia; Christian, Amy; Christian, Warren Jay et al. (2014) Prevalence of human papillomavirus types in invasive cervical cancers from 7 US cancer registries before vaccine introduction. J Low Genit Tract Dis 18:182-9
Hernandez, Brenda Y; Goodman, Marc T; Unger, Elizabeth R et al. (2014) Human papillomavirus genotype prevalence in invasive penile cancers from a registry-based United States population. Front Oncol 4:9
Morimoto, Y; Conroy, S M; Ollberding, N J et al. (2014) Ethnic differences in serum adipokine and C-reactive protein levels: the multiethnic cohort. Int J Obes (Lond) 38:1416-22
Du, Lin; Robles, Andrew J; King, Jarrod B et al. (2014) Crowdsourcing natural products discovery to access uncharted dimensions of fungal metabolite diversity. Angew Chem Int Ed Engl 53:804-9
Pettersson, Andreas; Graff, Rebecca E; Ursin, Giske et al. (2014) Mammographic density phenotypes and risk of breast cancer: a meta-analysis. J Natl Cancer Inst 106:
Morimoto, Yukiko; Beckford, Fanchon; Franke, Adrian A et al. (2014) Urinary isoflavonoid excretion as a biomarker of dietary soy intake during two randomized soy trials. Asia Pac J Clin Nutr 23:205-9
Park, Song-Yi; Kolonel, Laurence N; Lim, Unhee et al. (2014) Alcohol consumption and breast cancer risk among women from five ethnic groups with light to moderate intakes: the Multiethnic Cohort Study. Int J Cancer 134:1504-10

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