This application seeks renewed CCSG funding for the University of Hawai'i Cancer Center (UHCC), the state of Hawai'i and the Pacific Region's only institution where cancer research is performed. As an outpost in an area of the world with significant health disparities, UHCC serves a critical function in bringing cutting edge basic, translational, and clinical research on how to prevent and treat cancer within reach of the unique regional population. UHCC is part of the new Hawai'i Cancer Consortium (HCC) along with the 3 major hospital systems of Hawai'i. This consortium enables UHCC to develop a new clinical program and expand its clinical and translational research towards the development of new diagnostics and therapies. HCC institutions have committed $2.2 million annually towards UHCC through 2017, and UHCC receives $23.2M from the NCI and $18M from other peer-reviewed sources for a total of $41.2M in overall peer-reviewed grant funding. UHCC/HCC has recently recruited a new Director, along with 30 additional faculty members, who bring with them a broad-spectrum of scientific and clinical skills. These new recruits have helped UHCC/HCC continue to build and strengthen its basic-science foundations and to greatly enhance its ability to accelerate clinical and translational cancer research. To enhance their transdisciplinary and translational research, the three Research Programs (Cancer Biology, Cancer Epidemiology, and Cancer Prevention and Control) have been reorganized to provide a better focus in their areas of research. All Programs at UHCC are led by new Directors, each dedicated to increasing the vitality and interaction of their Programs. In addition, Planning and Evaluation has been restructured to create more opportunities for investigators to interact and stay abreast of opportunities for collaboration. This application requests support for 7 Shared Resources (Analytical Biochemistry, Biostatistics and Informatics, Genomics, Microscopy and Imaging, Nutrition Support, Pathology, and Clinical and Translational Research Services), and one developing Shared Resource (Animal Carcinogenesis). Major additions in research facilities include a new 150,000-sq ft UHCC research building opening in 2012 that will collectively house our growing faculty, as the University of Hawai'i has approved a total of 18 new tenure track positions for UHCC. This application describes continued excellence in basic and translational cancer research, and greatly strengthened clinical research leadership and infrastructure.
UHCC's mission is to reduce cancer burden through research, education, and service. UHCC investigators have access to a distinct environment in terms of ethnic diversity, as well as health disparities. This allows UHCC investigators in Hawaii to examine questions that are not easily broached within the continental states with the purpose of impacting patient care on a local, national, and global level. Moreover, UHCC provides Hawaii and the Pacific Region with access to high quality cancer research and care.
|Guo, Zhenying; Carbone, Michele; Zhang, Xing et al. (2017) Improving the Accuracy of Mesothelioma Diagnosis in China. J Thorac Oncol 12:714-723|
|Furuya, Hideki; Shimizu, Yoshiko; Tamashiro, Paulette M et al. (2017) Sphingosine kinase 1 expression enhances colon tumor growth. J Transl Med 15:120|
|Xie, Guoxiang; Wang, Xiaoning; Zhao, Aihua et al. (2017) Sex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes. Sci Rep 7:45232|
|Lloyd, Yukie M; Ngati, Elise P; Salanti, Ali et al. (2017) A versatile, high through-put, bead-based phagocytosis assay for Plasmodium falciparum. Sci Rep 7:14705|
|Park, Sungshim L; Murphy, Sharon E; Wilkens, Lynne R et al. (2017) Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study. PLoS One 12:e0178435|
|Conroy, Shannon M; Clarke, Christina A; Yang, Juan et al. (2017) Contextual Impact of Neighborhood Obesogenic Factors on Postmenopausal Breast Cancer: The Multiethnic Cohort. Cancer Epidemiol Biomarkers Prev 26:480-489|
|Huang, Madelyn C; Douillet, Christelle; Su, Mingming et al. (2017) Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure. Arch Toxicol 91:189-202|
|Boushey, Carol J; Spoden, Melissa; Delp, Edward J et al. (2017) Reported Energy Intake Accuracy Compared to Doubly Labeled Water and Usability of the Mobile Food Record among Community Dwelling Adults. Nutrients 9:|
|Mao, Weimin; Zhang, Xing; Guo, Zhenying et al. (2017) Association of Asbestos Exposure With Malignant Mesothelioma Incidence in Eastern China. JAMA Oncol 3:562-564|
|Harmon, Brook E; Wirth, Michael D; Boushey, Carol J et al. (2017) The Dietary Inflammatory Index Is Associated with Colorectal Cancer Risk in the Multiethnic Cohort. J Nutr 147:430-438|
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