Critical to many labs within Cancer Center is the ability to examine tissues and cells at the subcellular level, to count, isolate and measure cells, and to utilize non-invasive techniques to monitor tumorigenesis in mouse models. However, individual labs can rarely afford the state-of-the-art instrumentation required for many of these studies. Based on this need, a microscope core was created in 2002 and administered through the former Laboratory Instrumentation Shared Resource (LISR). The LISR's imaging capabilities have considerably expanded over the years with the acquisition of several important pieces of equipment, including a Leica TCS SP5 laser scanning confocal microscope, a laser capture tissue microdissection instrument, a time-lapse microscope with WeatherStation, and a IVIS Lumina imaging system for live animal studies. As a result of this growth, the former LISR is now the Microscopy and Imaging Share Resource (MISR), which serves as a centralized facility for access to imaging instruments within the Cancer Center. One important function of the MISR is to offer technical support to users and to properly maintain the complex instrumentation housed in the facility through annual maintenance services as well as routine calibrations. Moreover, the facility is responsible for upgrades, repairs, and acquisition of new equipment according to the needs of the cancer center researchers. Non-imaging services previously provided by the LISR, such as freezer monitoring, darkroom maintenance, and repairs of shared centrifuges, are now administered and supported entirely through institutional funds.

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National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Hawaii
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Guo, Zhenying; Carbone, Michele; Zhang, Xing et al. (2017) Improving the Accuracy of Mesothelioma Diagnosis in China. J Thorac Oncol 12:714-723
Furuya, Hideki; Shimizu, Yoshiko; Tamashiro, Paulette M et al. (2017) Sphingosine kinase 1 expression enhances colon tumor growth. J Transl Med 15:120
Xie, Guoxiang; Wang, Xiaoning; Zhao, Aihua et al. (2017) Sex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes. Sci Rep 7:45232
Lloyd, Yukie M; Ngati, Elise P; Salanti, Ali et al. (2017) A versatile, high through-put, bead-based phagocytosis assay for Plasmodium falciparum. Sci Rep 7:14705
Park, Sungshim L; Murphy, Sharon E; Wilkens, Lynne R et al. (2017) Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study. PLoS One 12:e0178435
Conroy, Shannon M; Clarke, Christina A; Yang, Juan et al. (2017) Contextual Impact of Neighborhood Obesogenic Factors on Postmenopausal Breast Cancer: The Multiethnic Cohort. Cancer Epidemiol Biomarkers Prev 26:480-489
Huang, Madelyn C; Douillet, Christelle; Su, Mingming et al. (2017) Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure. Arch Toxicol 91:189-202
Boushey, Carol J; Spoden, Melissa; Delp, Edward J et al. (2017) Reported Energy Intake Accuracy Compared to Doubly Labeled Water and Usability of the Mobile Food Record among Community Dwelling Adults. Nutrients 9:
Mao, Weimin; Zhang, Xing; Guo, Zhenying et al. (2017) Association of Asbestos Exposure With Malignant Mesothelioma Incidence in Eastern China. JAMA Oncol 3:562-564
Harmon, Brook E; Wirth, Michael D; Boushey, Carol J et al. (2017) The Dietary Inflammatory Index Is Associated with Colorectal Cancer Risk in the Multiethnic Cohort. J Nutr 147:430-438

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