Population Science in the Pacific (PSP) is a population research program in UHCC, with an emphasis on cancer epidemiology and cancer prevention. The mission of PSP is to conduct cancer research in the populations of Hawai?i and the Pacific to identify host, lifestyle and behavioral factors associated with cancer risk and outcome, and to use this knowledge to develop intervention for cancer prevention and improvement of patient survival. The Program has 28 full members and 12 associate members. The majority of members are located in UHCC and several UH professional schools, with a few from research institutions in the Pacific. Currently, PSP research is supported by $6.82M of peer-reviewed extramural funding (direct cost), including $4.7M from PSP members based at UHCC. Over the past 5 years, PSP members published 788 cancer-related research articles, and 40% of the publications were based on the studies through intra-programmatic collaboration while 11% were inter-programmatic. Inter-institution collaboration was 90%. To achieve the Program goal, PSP members conduct cancer research under three interconnected themes. Theme 1 is to understand what lifestyle; behavioral and environmental factors are associated with cancer risk. Theme 2 is to investigate genetic susceptibility and gene-environmental interaction in cancer and identify biomarkers involved in cancer initiation and progression. Theme 3 is to develop lifestyle and behavioral interventions to reduce cancer risk and to improve patient survival. These research themes build on our overarching hypothesis that cancer is a complex disease caused by the combination of many exogenous and endogenous factors coming from our environment, genetics, lifestyles and behaviors. These factors differ substantially by race and ethnicity, and may explain most of the racial/ethnic differences in cancer incidence and mortality. Many ethnic minorities reside in Hawai?i and the Pacific with distinct lifestyle and culture. This provides a unique opportunity to study race-specific cancer etiology in these populations and develop ethnicity-tailored intervention to address their cancer burden and health disparity. Over the years, we have investigated cancer risk and outcome in relation to ethnicity-specific lifestyles, including diet, nutrient intake, dietary pattern, physical activity, obesity, tobacco smoking, substance use, and social and behavioral attributes. We have conducted many large consortial studies to investigate genetic susceptibility and gene-environment interaction in cancer. We have also developed several Hawai?i- specific or ethnicity-tailored intervention programs to reduce cancer risk or prolong patient survival. Our efforts on community outreach and information dissemination are also relentless with specific targets and goals. In the next period of CCSG support, we will continue to conduct cutting-edge research under the 3 themes, expand our research to new emerging areas such as e-cigarette, cancer metabolomics and microbiome, and continue our efforts in translating clinical and epidemiological findings into interventions for cancer prevention and elimination of disparities.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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University of Hawaii
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Naderi, Ali (2018) SRARP and HSPB7 are epigenetically regulated gene pairs that function as tumor suppressors and predict clinical outcome in malignancies. Mol Oncol 12:724-755
Franke, Adrian A; Li, Xingnan; Menden, Ariane et al. (2018) Oxytocin analysis from human serum, urine, and saliva by orbitrap liquid chromatography-mass spectrometry. Drug Test Anal :
Fanidi, Anouar; Muller, David C; Yuan, Jian-Min et al. (2018) Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3). J Natl Cancer Inst 110:
Rohrmann, Sabine; Shvetsov, Yurii B; Morimoto, Yukiko et al. (2018) Self-reported dietary flavonoid intake and serum markers of inflammation: the multiethnic cohort. Cancer Causes Control 29:601-607
Faouzi, Malika; Neupane, Ram P; Yang, Jian et al. (2018) Areca nut extracts mobilize calcium and release pro-inflammatory cytokines from various immune cells. Sci Rep 8:1075
Nishioka, Scott T; Sato, Miles M; Wong, Linda L et al. (2018) Clinical and molecular sub-classification of hepatocellular carcinoma relative to alpha-fetoprotein level in an Asia-Pacific island cohort. Hepatoma Res 4:
Marciel, Michael P; Rose, Aaron H; Martinez, Verena et al. (2018) Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. Cancer Med 7:175-183
Shi, Geng-Xian; Yang, Won Seok; Jin, Ling et al. (2018) RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases. Proc Natl Acad Sci U S A 115:E190-E199
Citronberg, Jessica S; Wilkens, Lynne R; Le Marchand, Loic et al. (2018) Plasma lipopolysaccharide-binding protein and colorectal cancer risk: a nested case-control study in the Multiethnic Cohort. Cancer Causes Control 29:115-123
Panizza, Chloe E; Shvetsov, Yurii B; Harmon, Brook E et al. (2018) Testing the Predictive Validity of the Healthy Eating Index-2015 in the Multiethnic Cohort: Is the Score Associated with a Reduced Risk of All-Cause and Cause-Specific Mortality? Nutrients 10:

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