The Cancer Prevention and Control (CPC) Program has the overall goal to engage in scientific discovery across the cancer control continuum (i.e., primary prevention to survivorship) that translates into empirically- based interventions, clinical and public health practice, and policy strategies to reduce the cancer burden in New Jersey and beyond. CPC provides the platform for productive, collaborative, and impactful science, and interfaces with the Cancer Center for the translation of that science. CPC research centers on three main foci: 1) epidemiological research that evaluates environmental, neighborhood, heath care system, and behavioral risk factors and biomarkers and molecular tumor characteristics, which predict disparities in cancer risk, treatment, quality of life, and survival; 2) development of efficacious methods to reduce cancer risk behaviors and improve cancer outcomes through individual, family, and system-level interventions, and; 3) evaluation of tobacco use and development of efficacious smoking cessation interventions in vulnerable populations. Program members are organized into three groups based on expertise and relevance to the three aims. The CPC Program has 26 members who conduct extramurally-funded cancer prevention and control research in eight departments and three schools. Since 2011, CPC members have published 544 peer-reviewed manuscripts, with 22% intra-programmatic, 9% inter-programmatic, and 70% collaborative with other institutions. The CPC Program is home to ten fully cancer-focused, peer-reviewed funded research projects equivalent to an NIH R01 from nine different, independent PD/PIs. Members were awarded $6 million (annual direct costs) overall in cancer-relevant grant funding (five multi-PI), with $4.6 million (direct costs) from NCI. CPC has senior leadership with the appointments of Cristine Delnevo (tobacco) and Elisa Bandera (epidemiology) as Program Co-Leaders. In collaboration with the Associate Director for Cancer Prevention, Control, and Population Research, Sharon Manne (former program co-leader), the CPC?s research on cancer epidemiology, behavioral interventions to improve individual, family, and system-level outcomes, and tobacco control has expanded in breadth, depth, and extramural funding base. The CPC Program includes health psychologists, epidemiologists, primary care physicians, and public health scientists who collaborate on multi- disciplinary investigation across the cancer control continuum (e.g., primary prevention to survivorship). This research translates into empirically-based interventions, clinical and public health practice, and policy strategies to reduce the cancer burden in New Jersey and beyond. The multidisciplinary nature of CPC is reflected in the collaborative grants and publications. CPC, Part I: Narrative, Page 1 of 1; DRAFT 1/19/18 2:59 PM

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA072720-20
Application #
9632907
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-03-01
Budget End
2020-02-29
Support Year
20
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Rbhs -Cancer Institute of New Jersey
Department
Type
DUNS #
078728091
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901
Zhu, Sining; Jin, Juan; Gokhale, Samantha et al. (2018) Genetic Alterations of TRAF Proteins in Human Cancers. Front Immunol 9:2111
Perekatt, Ansu O; Shah, Pooja P; Cheung, Shannon et al. (2018) SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut Epithelium. Cancer Res 78:4878-4890
Llanos, Adana A M; Tsui, Jennifer; Rotter, David et al. (2018) Factors associated with high-risk human papillomavirus test utilization and infection: a population-based study of uninsured and underinsured women. BMC Womens Health 18:162
Hadigol, Mohammad; Khiabanian, Hossein (2018) MERIT reveals the impact of genomic context on sequencing error rate in ultra-deep applications. BMC Bioinformatics 19:219
Severson, Eric A; Riedlinger, Gregory M; Connelly, Caitlin F et al. (2018) Detection of clonal hematopoiesis of indeterminate potential in clinical sequencing of solid tumor specimens. Blood 131:2501-2505
Shih, Weichung Joe; Lin, Yong (2018) Relative efficiency of precision medicine designs for clinical trials with predictive biomarkers. Stat Med 37:687-709
Ding, Qiang; Gaska, Jenna M; Douam, Florian et al. (2018) Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease. Proc Natl Acad Sci U S A 115:E6310-E6318
Winer, Benjamin Y; Shirvani-Dastgerdi, Elham; Bram, Yaron et al. (2018) Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med 10:
Modi, Parth K; Wang, Ye; Kirk, Peter S et al. (2018) The Receipt of Industry Payments is Associated With Prescribing Promoted Alpha-blockers and Overactive Bladder Medications. Urology 117:50-56
Dai, Zhuqing; Feng, Simin; Liu, Anna et al. (2018) Anti-inflammatory effects of newly synthesized ?-galacto-oligosaccharides on dextran sulfate sodium-induced colitis in C57BL/6J mice. Food Res Int 109:350-357

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