The Analytic Microscopy Core Facility (AMC) was established in 1999 to serve as a centralized shared resource that provides scientific and technical expertise in optical microscopy applications. The AMC is an invaluable resource for Cancer Center researchers interested in intracellular trafficking and sub-cellular localization of molecules involved in protein phosphorylation, signal transduction, cell cycle progression, cellto- cell contact, cell motility, cell differentiation, apoptosis, angiogenesis, invasion or metastasis, DNA repair, and gene expression and drug discovery. The AMC's primary goal is to provide Cancer Center investigators with access to the latest optical microscopy imaging systems, including: widefield fluorescence and confocal microscopy;image analysis and laser capture microdissection. In the last five years the AMC Facility has actively contributed significantly to the science of the Cancer Center. Work supported by the AMC Facility has resulted in nearly 100 publications since 2000. The AMC Core has added new state-of-art instrumentation resulting in a steady rise in usage of the Core Facility by the Cancer Center investigators. The future plans of the AMC Facility are to maximize the potential of the current instruments and further develop advanced microscopy applications. To achieve these goals the AMC Facility will implement a series of initiatives to educate and train intra- and extramurally-funded investigators in the use of advanced microscopy and imaging techniques. In addition the Core will focus on facilitating the investigators awareness and access to confocal and fluorescence microscopy. To this end the AMC Facility will offer a series of general microscopy workshops in these areas, to assist in growing the knowledge and skill base of the facility's users.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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H. Lee Moffitt Cancer Center & Research Institute
United States
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Tauro, Marilena; Shay, Gemma; Sansil, Samer S et al. (2017) Bone-Seeking Matrix Metalloproteinase-2 Inhibitors Prevent Bone Metastatic Breast Cancer Growth. Mol Cancer Ther 16:494-505
Davis, Stacy N; Christy, Shannon M; Chavarria, Enmanuel A et al. (2017) A randomized controlled trial of a multicomponent, targeted, low-literacy educational intervention compared with a nontargeted intervention to boost colorectal cancer screening with fecal immunochemical testing in community clinics. Cancer 123:1390-1400
Song, Jinming; Hussaini, Mohammad; Zhang, Hailing et al. (2017) Comparison of the Mutational Profiles of Primary Myelofibrosis, Polycythemia Vera, and Essential Thrombocytosis. Am J Clin Pathol 147:444-452
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Heit, Claire; Marshall, Stephanie; Singh, Surrendra et al. (2017) Catalase deletion promotes prediabetic phenotype in mice. Free Radic Biol Med 103:48-56
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Liu, Ying; Balagurunathan, Yoganand; Atwater, Thomas et al. (2017) Radiological Image Traits Predictive of Cancer Status in Pulmonary Nodules. Clin Cancer Res 23:1442-1449
Chen, Yi; Fisher, Kate J; Lloyd, Mark et al. (2017) Multiplexed Liquid Chromatography-Multiple Reaction Monitoring Mass Spectrometry Quantification of Cancer Signaling Proteins. Methods Mol Biol 1647:19-45
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