The Translational Research Core (TRC) is designed to facilitate high quality translational research at the Moffitt Cancer Center. The TRC provides a means to generate pre-clinical data to support investigator initiated trials and resources to quantify the level/activity of molecular targets from clinical specimens obtained from trials. The functionality provided within the Core provides a vital resource for investigators to design and conduct early phase clinical research of novel agents. The Core's overall goals are to provide efficient and proper collection, handling and processing of biological samples, perform sensitive and specific assays and provide the ability to model the data generated. The TRC continues to increase the number of investigators utilizing their services. The Core has also witnessed a greater number of scientific programs requiring services since the last renewal. The capacity of the pharmacologic section has been expanded by the inclusion of a new UHPLC/Tandem Mass Spectrometry system (Thermo Scientific, Accela/TSQ Quantum). Regarding analyses of pharmacodynamic molecular endpoints, the number of active projects continues to grow and is neariy equally divided between clinical and preclinical projects. The Core requests CCSG Support of $125,995, which is 23% of its operational budget.

Public Health Relevance

The Translational Research Core Facility provides researchers with novel approaches and access to the latest technologies with respect to pharmacokinetic drug quantitation and analysis, measurement of pharmacodynamic endpoints, and high-throughput apoptosis assays and combination index analysis for drug interactions. The core is uniquely positioned to provide researchers with a cost-effective, well-managed facility to accomplish their goals.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA076292-14
Application #
8491603
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-06-22
Budget End
2013-01-31
Support Year
14
Fiscal Year
2012
Total Cost
$70,595
Indirect Cost
$29,987
Name
H. Lee Moffitt Cancer Center & Research Institute
Department
Type
DUNS #
139301956
City
Tampa
State
FL
Country
United States
Zip Code
33612
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