Analyzing, managing, and interpreting data accumulated in the age of accessible genomics involves tremendous challenges. A shared resource consisting of informatics and computational scientists, a group of specially trained professionals who understand both biomedical and computer science methodologies, fills the collaboration gap between members, IT professionals, and computational scientists. The overall goal of the Cancer Informatics Core (CIC) is to facilitate the biomedical and translational research of Moffitt Cancer Center (MCC) members through implementation and development of methods and tools to record, integrate, manage, analyze, visualize, and share biomedical, behavioral, and clinical data. To accomplish its goal, the CIC's Specific Aims are to: 1) Support members' 'omics projects with bioinformatics project design, analysis, biological interpretation, and visualizations: The CIC provides bioinformatics and big data analysis and collaborates closely with the Biostatistics Core (BC) to provide seamless analytical services for member projects involving expression profiling, next-generation sequencing, and proteomics. Services include QC, normalization, batch correction, phenotypic analysis, and biological pathway enrichment. 2) Support members' data management and reporting needs with study-specific informatics tools: Complex, study-specific data are collected for member biomedical research studies, including large multi- project studies such as SPOREs. 3) Provide educational opportunities to train members and staff on the use of bioinformatics resources and tools: Public resources are available for members and staff to extract biomedical data and knowledge, leveraging work of the entire scientific community. The CIC provides training for members for awareness of and access to these resources directly. The CIC includes three faculty members, a core facility manager, five staff scientists, and three software developers. CIC bioinformatics faculty devote 50-70% effort to MCC collaborative research activities, supported by CCSG, other grant, and institutional funding. Staff scientists and software developers are dedicated 100% to the CIC, supported by CCSG funding, chargebacks, and institutional support. CIC faculty and staff members are involved in all stages of scientific research, from supporting experimental design (with the Biostatistics Core) to publication of research findings. The CIC has provided significant impact in member research studies through bioinformatics analysis in genomics, proteomics, and expression profiling resulting in high-impact publications in journals such as Nature Genetics and Cancer Research. Over the past five years, the CIC has supported scientific projects of members of all programs, resulting in 62 publications. In the most recent fiscal year, the CIC supported 35 members, with 84% of usage by peer-review-funded members.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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H. Lee Moffitt Cancer Center & Research Institute
United States
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Davis, Stacy N; Govindaraju, Swapamthi; Jackson, Brittany et al. (2018) Recruitment Techniques and Strategies in a Community-Based Colorectal Cancer Screening Study of Men and Women of African Ancestry. Nurs Res 67:212-221
Martínez, Úrsula; Brandon, Thomas H; Sutton, Steven K et al. (2018) Associations between the smoking-relatedness of a cancer type, cessation attitudes and beliefs, and future abstinence among recent quitters. Psychooncology 27:2104-2110
Perales-Puchalt, Alfredo; Perez-Sanz, Jairo; Payne, Kyle K et al. (2018) Frontline Science: Microbiota reconstitution restores intestinal integrity after cisplatin therapy. J Leukoc Biol 103:799-805
Nelson, Ashley M; Jim, Heather S L; Small, Brent J et al. (2018) Sleep disruption among cancer patients following autologous hematopoietic cell transplantation. Bone Marrow Transplant 53:307-314
Singh, Kshipra; Coburn, Lori A; Asim, Mohammad et al. (2018) Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Cancer Res 78:4303-4315
Kasting, Monica L; Giuliano, Anna R; Reich, Richard R et al. (2018) Hepatitis C Virus Screening Trends: Serial Cross-Sectional Analysis of the National Health Interview Survey Population, 2013-2015. Cancer Epidemiol Biomarkers Prev 27:503-513
Denson, Aaron; Burke, Nancy; Wapinsky, Georgine et al. (2018) Clinical Outcomes of Patients With Gastrointestinal Malignancies Participating in Phase I Clinical Trials. Am J Clin Oncol 41:133-139
Betts, Brian C; Bastian, David; Iamsawat, Supinya et al. (2018) Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation. Proc Natl Acad Sci U S A 115:1582-1587
Pidala, Joseph; Beato, Francisca; Kim, Jongphil et al. (2018) In vivo IL-12/IL-23p40 neutralization blocks Th1/Th17 response after allogeneic hematopoietic cell transplantation. Haematologica 103:531-539
Hampras, S S; Tommasino, M; Zhao, Y et al. (2018) Cross-sectional associations between cutaneous viral infections and regulatory T lymphocytes in circulation. Br J Dermatol :

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